Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

A serine/threonine protein kinase with GTPase activity that contains 12 LEUCINE-rich repeats in its central region and 7 WD repeats C-terminal to its kinase and GTPase domains. It localizes to TRANSPORT VESICLES; the OUTER MITOCHONDRIAL MEMBRANE; and the GOLGI APPARATUS. It functions in PROTEIN TRANSPORT; regulates neuron morphology in the central nervous system, and also functions in the trafficking of SYNAPTIC VESICLES. Mutations in the LRRK2 gene have been identified in autosomal dominant cases of PARKINSON DISEASE (PARK8).

Also Known As:

Dardarin Protein; LRRK2 Protein; PARK8 Protein; Leucine Rich Repeat Serine Threonine Protein Kinase 2

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9677
        Protein Serine-Threonine Kinases: 3588
        Leucine-Rich Repeat Serine-Threonine Protein Kinase-2: 41
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein Serine-Threonine Kinases: 3588
      - Leucine-Rich Repeat Serine-Threonine Protein Kinase-2: 41
  - Parkinson Disease Associated Proteins: 1
    - Leucine-Rich Repeat Serine-Threonine Protein Kinase-2: 41

zebrafish LRRK2 protein

Bio-Agent Context: Research Results