|1.||Agyeman, Akwasi: 6 articles (06/2014 - 01/2010)|
|2.||Houghton, Janet A: 6 articles (06/2014 - 01/2010)|
|3.||Mazumdar, Tapati: 6 articles (06/2014 - 01/2010)|
|4.||Shi, Ting: 5 articles (09/2011 - 01/2010)|
|5.||DeVecchio, Jennifer: 3 articles (01/2013 - 02/2011)|
|6.||Ishidou, Yasuhiro: 2 articles (03/2015 - 10/2011)|
|7.||Maeda, Shingo: 2 articles (03/2015 - 10/2011)|
|8.||Yamamoto, Takuya: 2 articles (03/2015 - 10/2011)|
|9.||Nagano, Satoshi: 2 articles (03/2015 - 10/2011)|
|10.||Setoguchi, Takao: 2 articles (03/2015 - 10/2011)|
01/01/2014 - "Inhibition of autophagy potentiates the efficacy of Gli inhibitor GANT-61 in MYCN-amplified neuroblastoma cells."
04/01/2013 - "GANT61 sensitivity positively correlated to GLI1 and negatively to MYCN expression in the neuroblastoma cell lines tested. "
04/01/2013 - "Furthermore, GANT61 enhanced the effects of chemotherapeutic drugs used in the treatment of neuroblastoma in an additive or synergistic manner and reduced the growth of established neuroblastoma xenografts in nude mice. "
04/01/2013 - "Using compounds blocking SMO (cyclopamine and SANT1) or GLI1/GLI2 (GANT61) activity revealed that inhibition of HH signaling at the level of GLI was most effective in reducing neuroblastoma growth. "
04/01/2013 - "GANT61 downregulated GLI1, c-MYC, MYCN and Cyclin D1 expression and induced apoptosis of neuroblastoma cells. "
01/30/2015 - "The Gli inhibitor GANT61 induces apoptosis in various cancer cell models, and has been associated directly with Gli inhibition. "
12/15/2014 - "As compared to vehicle-treated control, about 50% tumor growth inhibition occurs in mice receiving GANT-61 treatment. "
06/30/2014 - "Data establish the specificity of GANT61 for targeting GLI, and substantiate the critical role of GLI in cancer cell survival. "
03/01/2013 - "Furthermore, GANT-61 inhibited CSC tumor growth which was associated with up-regulation of DR4 and DR5 expression, and suppression of Gli1, Gli2, Bcl-2, CCND2 and Zeb1 expression in tumor tissues derived from NOD/SCID IL2Rγ null mice. "
03/01/2013 - "Humanized NOD/SCID/IL2R gamma(null) mice were used to examine the effects of GANT-61 on CSC's tumor growth. "
01/01/2014 - "The present study sought to determine whether the Hedgehog (Hh) pathway is active and regulates the cell growth of cultured malignant pleural mesothelioma (MPM) cells and to evaluate the efficacy of pathway blockade using smoothened (SMO) antagonists (SMO inhibitor GDC-0449 or the antifungal drug itraconazole [ITRA]) or Gli inhibitors (GANT61 or the antileukemia drug arsenic trioxide [ATO]) in suppressing MPM viability. "
|4.||Osteosarcoma (Osteogenic Sarcoma)
01/01/2014 - "Furthermore, GANT61 inhibited proliferation and colony formation in all three canine osteosarcoma cell lines. "
01/01/2014 - "Treatment of canine osteosarcoma cells with GANT61 resulted in decreased expression of GLI1, GLI2, PTCH1, and PAX6. "
03/15/2015 - "In addition, the combination of Hh inhibitors including ATO, vismodegib and GANT61 prevented migration and metastasis of osteosarcoma cells. "
01/01/2014 - "In this study, we examined the expression and regulation of GLI transcription factors in multiple canine osteosarcoma cell lines and analyzed the effects of inhibiting GLI with GANT61, a GLI-specific inhibitor. "
|5.||Ovarian Neoplasms (Ovarian Cancer)
|3.||arsenic trioxide (Trisenox)
|5.||Transcription Factors (Transcription Factor)
|6.||Small Interfering RNA (siRNA)
|9.||Telomerase (Telomerase Reverse Transcriptase)
|10.||Complementary DNA (cDNA)
|1.||Heterologous Transplantation (Xenotransplantation)