|1.||Jones, Ronald N: 5 articles (09/2012 - 07/2011)|
|2.||Farrell, David J: 4 articles (09/2012 - 07/2011)|
|3.||Liverman, Lisa C: 4 articles (04/2012 - 07/2011)|
|4.||McIntyre, Gail: 3 articles (11/2013 - 12/2011)|
|5.||Flamm, Robert K: 3 articles (04/2012 - 12/2011)|
|6.||Biedenbach, Douglas J: 3 articles (04/2012 - 07/2011)|
|7.||Davenport, J Michael: 2 articles (11/2013 - 12/2011)|
|8.||Turner, Lisa L: 2 articles (11/2013 - 09/2012)|
|9.||Almenoff, June: 2 articles (11/2013 - 12/2011)|
|10.||Morrow, Brian J: 2 articles (12/2011 - 05/2010)|
12/01/2011 - "Efficacy of a new fluoroquinolone, JNJ-Q2, in murine models of Staphylococcus aureus and Streptococcus pneumoniae skin, respiratory, and systemic infections."
07/01/2011 - "In this study, the in vitro activity of JNJ-Q2 was evaluated against 511 selected Staphylococcus aureus samples isolated in 2008-2009 from patients with acute bacterial skin and skin structure infections in the United States by using reference methodology. "
09/01/2012 - "Activity of JNJ-Q2 against Staphylococcus aureus isolated from patients with acute bacterial skin and skin-structure infection obtained during a Phase 2 clinical trial."
12/01/2011 - "JNJ-Q2 demonstrated activity that was comparable or superior to the activity of fluoroquinolone or antistaphylococcal comparators in several local and systemic skin infection models performed with both S. "
12/01/2011 - "JNJ-Q2 and comparators were also evaluated in an acute murine skin infection model using a community-acquired MRSA strain and in an established skin infection (ESI) model using a hospital-acquired strain, for which the selection of resistant mutants was also determined. "
12/01/2011 - "The in vivo efficacy of JNJ-Q2, a new broad-spectrum fluoroquinolone (FQ), was evaluated in a murine septicemia model with methicillin-susceptible Staphylococcus aureus (MSSA) and methicillin-resistant S. "
12/01/2011 - "JNJ-Q2 demonstrated activity in the MSSA septicemia model that was comparable to that moxifloxacin (JNJ-Q2 50% effective dose [ED(50)], 0.2 mg/kg of body weight administered subcutaneously [s.c.] and 2 mg/kg administered orally [p.o.]) and activity in the MRSA septicemia model that was superior to that of vancomycin (JNJ-Q2 ED(50), 1.6 mg/kg administered s.c.). "
12/01/2011 - "The results suggest JNJ-Q2 shows promise as an effective treatment for ABSSSI, demonstrating (i) efficacy for early clinical response (i.e., lack of spread of lesions and absence of fever at 48 to 72 h), and (ii) cure rates for ABSSSI pathogens (especially MRSA) consistent with the historical literature."
11/01/2013 - "A Phase 2 study of the novel fluoroquinolone JNJ-Q2 in community-acquired bacterial pneumonia."
04/01/2012 - "Activity of JNJ-Q2, a new fluoroquinolone, tested against contemporary pathogens isolated from patients with community-acquired bacterial pneumonia."
04/01/2012 - "JNJ-Q2 is a broad-spectrum fluoroquinolone with bactericidal activity against Gram-positive and Gram-negative pathogens and is currently in clinical development for the treatment of community-acquired bacterial pneumonia (CABP) and acute bacterial skin and skin-structure infections. "
12/01/2011 - "JNJ-Q2 is in clinical development for the treatment of acute bacterial skin and skin-structure infections (ABSSSIs) and community-acquired bacterial pneumonia. "
08/01/2011 - "JNJ-Q2 is a novel fluorinated 4-quinolone in development for treatment of acute bacterial skin and skin structure infection and community-acquired bacterial pneumonia. "
|5.||Respiratory Tract Infections (Respiratory Tract Infection)
12/01/2011 - "pneumoniae lower respiratory tract infection model, JNJ-Q2 displayed activity (ED(50), 1.9 mg/kg administered s.c. "
05/01/2010 - "In conclusion, JNJ-Q2 exhibits a range of antibacterial activities in vitro that is supportive of its further evaluation as a potential new agent for the treatment of skin and respiratory tract infections."
|3.||7- (3- (2- amino- 1- fluoroethylidene)- 1- piperidinyl)- 1- cyclopropyl- 6- fluoro- 1,4- dihydro- 8- methoxy- 4- oxo- 3- quinolinecarboxylic acid