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7- (4- fluorobenzylamino)- 1,3,4,8- tetrahydropyrrolo(4,3,2- de)quinolin- 8(1H)- one

has antineoplastic activity; structure in first source

Also Known As:

FBA-TPQ

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrroles: 369
      - 7-(4-fluorobenzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Quinolones: 2938
        7-(4-fluorobenzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one: 4

Experts

1.	Nadkarni, Dwayaja H: 4 articles (05/2012 - 05/2009)
2.	Velu, Sadanandan E: 4 articles (05/2012 - 05/2009)
3.	Wang, Wei: 4 articles (05/2012 - 05/2009)
4.	Zhang, Ruiwen: 4 articles (05/2012 - 05/2009)
5.	Murugesan, Srinivasan: 3 articles (05/2012 - 05/2009)
6.	Rayburn, Elizabeth R: 2 articles (06/2010 - 05/2009)
7.	Voruganti, Sukesh: 1 article (05/2012)
8.	Wang, Ming-Hai: 1 article (05/2012)
9.	Xu, Hongxia: 1 article (05/2012)
10.	Zhang, Xiangrong: 1 article (05/2012)

Related Diseases

1.	Neoplasms (Cancer) 05/15/2009 - "Moreover, FBA-TPQ inhibited the growth of breast cancer xenograft tumors in nude mice in a dose-dependent manner. " 01/01/2011 - "The present study was designed to determine the biological effects of novel marine alkaloid analog 7-(4-fluorobenzylamino)-1,3,4,8-tetrahydropyrrolo[4,3,2-de]quinolin-8(1H)-one (FBA-TPQ) on human ovarian cancer cells for its anti-tumor potential and the underlying mechanisms as a novel chemotherapeutic agent. "
2.	Ovarian Neoplasms (Ovarian Cancer) 01/01/2011 - "In conclusion, FBA-TPQ exhibits significant anticancer activity against ovarian cancer cells, with minimal toxicity to non-tumorigenic human IOSE-144 cells, indicating that it may be a potential therapeutic agent for ovarian cancer." 01/01/2011 - "FBA-TPQ exerted potent cytotoxicity against human ovarian cancer A2780 and OVCAR-3 cells as an effective inhibitor of cell growth and proliferation, while exerting lesser effects on non-tumorigenic IOSE-144 cells. " 01/01/2011 - "Human ovarian cancer cells (A2780 and OVCAR-3), and Immortalized non-tumorigenic human Ovarian Surface Epithelial cells (IOSE-144), were exposed to FBA-TPQ for initial cytotoxicity evaluation (via MTS assay kit, Promega). " 01/01/2011 - "The present study was designed to determine the biological effects of novel marine alkaloid analog 7-(4-fluorobenzylamino)-1,3,4,8-tetrahydropyrrolo[4,3,2-de]quinolin-8(1H)-one (FBA-TPQ) on human ovarian cancer cells for its anti-tumor potential and the underlying mechanisms as a novel chemotherapeutic agent. "
3.	Prostatic Neoplasms (Prostate Cancer) 06/01/2010 - "The results presented herein support the further development of FBA-TPQ as a novel agent for prostate cancer." 06/01/2010 - "FBA-TPQ exhibited dose-dependent cytotoxicity in the low micromolar range, inhibited proliferation, caused cell cycle arrest, and induced apoptosis in prostate cancer cell lines. " 06/01/2010 - "The effects of FBA-TPQ on human (LNCaP and PC3) and murine (TRAMP C1) prostate cancer cells were evaluated. " 06/01/2010 - "FBA-TPQ, a novel marine-derived compound as experimental therapy for prostate cancer."
4.	Pancreatic Neoplasms (Pancreatic Cancer) 05/01/2012 - "Our results indicate that FBA-TPQ is a potential therapeutic agent for pancreatic cancer, providing a basis for future preclinical and clinical development." 05/01/2012 - "Our results demonstrated that FBA-TPQ inhibited pancreatic cancer cell growth, induced apoptosis, and caused cell cycle arrest in vitro. "
5.	Breast Neoplasms (Breast Cancer) 05/15/2009 - "Moreover, FBA-TPQ inhibited the growth of breast cancer xenograft tumors in nude mice in a dose-dependent manner. " 05/15/2009 - "Our preclinical data indicate that FBA-TPQ is a potential therapeutic agent for breast cancer, providing a basis for the development of the compound as a novel anticancer agent."

Related Drugs and Biologics

1.	Alkaloids
2.	Antineoplastic Agents (Antineoplastics)
3.	Promega

Related Therapies and Procedures

1.	Investigational Therapies (Experimental Therapy)