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cyclo(Arg-Gly-Asp-Tyr-Lys)

structure in first source

Also Known As:

cRGDyK peptide; cyclicRGDYK

Networked: 7 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Cyclic Peptides: 530
    - cyclo(Arg-Gly-Asp-Tyr-Lys): 7
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Cyclic Peptides: 530
    - cyclo(Arg-Gly-Asp-Tyr-Lys): 7

Experts

1.	Gao, Jie: 1 article (08/2021)
2.	Li, Bo: 1 article (08/2021)
3.	Li, Dedong: 1 article (08/2021)
4.	Lu, Yuechun: 1 article (08/2021)
5.	Sun, Jian: 1 article (08/2021)
6.	Wang, Haiyun: 1 article (08/2021)
7.	Wang, Ying: 1 article (08/2021)
8.	Yang, Chenyi: 1 article (08/2021)
9.	Yu, Mingdong: 1 article (08/2021)
10.	Chen, Hui: 1 article (01/2021)

Related Diseases

1.	Glioma (Gliomas) 08/01/2021 - "The results suggested that the cRGDyK peptide significantly facilitated the ability of liposomes to transfer procaine across the BBB and improved the cellular uptake of procaine by C6 glioma cells. "
2.	Melanoma (Melanoma, Malignant) 01/01/2020 - "In this study, we aimed at the investigation of the role of the PC in determining the behavior of cRGDyk peptide-unconjugated and -conjugated NPs (uNPs and cNPs) exhibiting different physicochemical properties and their interaction with melanoma on in vitro and in vivo levels. " 01/05/2021 - "In vitro studies demonstrated that cRGDyk-2-ME@ICG-TSLs effectively induced drug accumulation and cytotoxicity in NIR laser-irradiated B16-F10 melanoma cells using dual targeting based on the cRGDyk peptide and temperature sensitivity. "
3.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 08/15/2015 - "This study aimed to prepare efficient cRGDyK peptide-decorated micelles for the targeted therapy of non-small-cell lung cancer (NSCLC). " 08/15/2015 - "Systemic delivery of micelles loading with paclitaxel using N-succinyl-palmitoyl-chitosan decorated with cRGDyK peptide to inhibit non-small-cell lung cancer."
4.	Neoplasms (Cancer) 01/01/2016 - "Herein, we reported a novel cRGDyK peptide modified pH-sensitive nanoparticle system based on poly(ethylene glycol)-poly(2,4,6-trimethoxy benzylidene-pentaerythritol carbonate) (PEG-PTMBPEC) diblock copolymer, which was expected to destroy tumor angiogenesis and kill tumor cells simultaneously. " 01/01/2016 - "Blank NPs were non-toxic to both tumor cells and normal cells, while DOX-loaded cRGDyK peptide modified NPs (cRGDyK-NPs) exhibited the pronounced cytotoxicity against B16 cells and human umbilical vein endothelial cells (HUVEC) overexpressing αvβ3 integrin receptors. " 08/15/2015 - "cRGDyK peptide is a ligand that can target tumors via specific binding integrin receptor overexpressed on tumor neovascularization and cells. " 05/26/2015 - "Herein, the effective antitumor drug PTX is used to induce the self-assembly of HSA modified with either a photosensitizer chlorin e6 (Ce6), which at the same time serves as a chelating agent for Mn(2+) to enable magnetic resonance imaging, or acyclic Arg-Gly-Asp (cRGDyK) peptide that targets αvβ3-integrin overexpressed on tumor angiogenic endothelium. "
5.	Liver Cirrhosis (Hepatic Cirrhosis) 07/01/2010 - "Thus, the cRGDyK peptide represented a new agent potentially useful for the diagnosis of liver fibrosis."

Related Drugs and Biologics

1.	Procaine (Novocaine)
2.	Liposomes (Liposome)
3.	Micelles
4.	Integrins
5.	Chitosan
6.	Photosensitizing Agents (Photosensitizers)
7.	Paclitaxel (Taxol)
8.	Ligands
9.	Chelating Agents
10.	Antineoplastic Agents (Antineoplastics)

Related Therapies and Procedures

1.	Therapeutics
2.	Lasers (Laser)