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powelline

isolated from Amaryllidaceae; structure in first source

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Phenanthridines: 3
      - powelline: 2

Experts

1.	Green, Ezekiel: 1 article (01/2020)
2.	Makatini, Maya Mellisa: 1 article (01/2020)
3.	Mavumengwana, Vuyo: 1 article (01/2020)
4.	Mekuto, Lukhanyo: 1 article (01/2020)
5.	Sebola, Tendani E: 1 article (01/2020)
6.	Uche-Okereafor, Nkemdinma C: 1 article (01/2020)

Related Diseases

1.	Stomach Neoplasms (Stomach Cancer) 03/13/2023 - "In gastric cancer cell line AGS, the best results (lower cell viability percentages) were obtained for Crinum jagus (48.06 ± 3.35%) and Eucharis bonplandii (45.79 ± 3.05%) at 30 µg/mL. The research focused on evaluating the identified alkaloids on the Bcl-2 protein family (Mcl-1 and Bcl-xL) and HK2, where the in vitro, in silico and statistical results suggest that powelline and buphanidrine alkaloids could present cytotoxic activity. "
2.	Carcinoma (Carcinomatosis) 01/01/2020 - "Pseudomonas cichorii exhibited broad antibacterial activity against both Gram-negative and Gram-positive pathogenic bacteria while Arthrobacter pascens displayed the least MIC of 0.0625 mg/mL. Bacillus safensis crude extracts were the only sample that showed notable cell reduction of 50% against A549 lung carcinoma cells at a concentration of 100 μg/mL. Metabolite profiling of Bacillus safensis, Pseudomonas cichorii, and Arthrobacter pascens crude extracts revealed the presence of known antibacterial and/or anticancer agents such as lycorine (1), angustine (2), crinamidine (3), vasicinol (4), and powelline. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Alkaloids
3.	buphanidrine
4.	Complex Mixtures
5.	Antineoplastic Agents (Antineoplastics)
6.	lycorine
7.	angustine