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5,7,3'-trihydroxy-3,4'-dimethoxyflavone

induced cell death in human leukemia cells is dependent on caspases and activates the MAPK pathway; structure in first source

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavones: 446
        5,7,3'-trihydroxy-3,4'-dimethoxyflavone: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavones: 446
        5,7,3'-trihydroxy-3,4'-dimethoxyflavone: 2

Experts

1.	Estévez, Francisco: 2 articles (02/2011 - 05/2010)
2.	Quintana, José: 2 articles (02/2011 - 05/2010)
3.	Torres, Fernando: 2 articles (02/2011 - 05/2010)

Related Diseases

1.

05/01/2010 - "In this study we investigated the effect of 5,7,3'-trihydroxy-3,4'-dimethoxyflavone (THDF) on viability of nine human tumor cell lines and found that it was highly cytotoxic against leukemia cells. "
02/01/2011 - "The derivative of quercetin, 5,7,3'-trihydroxy-3,4'-dimethoxyflavone (THDF), is a natural flavonoid that inhibits cell proliferation and induces apoptosis in human leukemia cells. "

Related Drugs and Biologics

1.	Quercetin
2.	Flavonoids