saurolactam

an NSAID isolated from the Chinese lizard Saururus chinensis; structure in first source

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

1.	Osteosarcoma (Osteogenic Sarcoma) 07/01/2015 - "The present study indicates that saurolactam might represent a new promising agent to improve osteosarcoma treatment. " 07/01/2015 - "Saurolactam Inhibits Proliferation, Migration, and Invasion of Human Osteosarcoma Cells." 07/01/2015 - "Here, we demonstrate that saurolactam shows anti-cancer activity against human osteosarcoma cells. " 07/01/2015 - "Western analysis suggested that saurolactam treatment resulted in a reduction of Akt/PKB, phospho-Ser473-Akt, c-Myc, and S-phase kinase-associated protein 2 (Skp2) in MG-63 and HOS osteosarcoma cells. " 07/01/2015 - "Saurolactam treatment inhibited proliferation of human osteosarcoma cell lines MG-63 and HOS and decreased colony formation in soft agar in a dose-dependent manner. "
2.	Neoplasms (Cancer) 07/01/2015 - "Here, we demonstrate that saurolactam shows anti-cancer activity against human osteosarcoma cells. "
3.	Body Weight (Weight, Body) 07/01/2015 - "Intraperitoneal administration of saurolactam at 25 mg/kg of body weight for 21 days dramatically inhibited the growth of MG-63 xenografts in nude mice. "

1.	S-Phase Kinase-Associated Proteins (Skp1 Protein)
2.	Agar