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GO 201

a MUC1 inhibitor with antineoplastic activity

Also Known As:

GO-201; GO201 cpd

Networked: 7 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - GO 201: 7

Experts

1.	Ahmad, Rehan: 3 articles (09/2010 - 06/2009)
2.	Kharbanda, Surender: 3 articles (09/2010 - 06/2009)
3.	Kufe, Donald: 3 articles (09/2010 - 06/2009)
4.	Yin, Li: 3 articles (09/2010 - 06/2009)
5.	Avigan, David: 2 articles (09/2010 - 06/2009)
6.	Kawano, Takeshi: 2 articles (09/2010 - 06/2009)
7.	Joshi, Maya Datt: 2 articles (11/2009 - 06/2009)
8.	Raina, Deepak: 2 articles (11/2009 - 06/2009)
9.	Chatterjee, Suvro: 1 article (01/2022)
10.	Demmers, Jeroen: 1 article (01/2022)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2009 - "Significantly, GO-201 treatment of DU145 and PC3 xenografts growing in nude mice resulted in complete tumor regression and prolonged lack of recurrence. " 01/01/2017 - "Further, suppression of MUC1 cellular activity with GO-201 enhanced EREG production in lung cancer cells, which in turn protected cancer cells from GO-201-induced cell death. " 06/15/2009 - "Administration of GO-201 to nude mice bearing human breast tumor xenografts was associated with loss of tumorigenicity and extensive necrosis, which results in prolonged regression of tumor growth. " 01/01/2012 - "Furthermore, GO-201, the peptide inhibitor of MUC1-c, was effective in reducing tumor burden in pancreatic cancer mouse model. "
2.	Pancreatic Neoplasms (Pancreatic Cancer) 01/01/2012 - "Furthermore, GO-201, the peptide inhibitor of MUC1-c, was effective in reducing tumor burden in pancreatic cancer mouse model. "
3.	Necrosis 09/01/2010 - "Primary CML blasts expressing MUC1 similarly responded to GO-201 with induction of a more differentiated phenotype and late apoptosis/necrosis. " 06/15/2009 - "Administration of GO-201 to nude mice bearing human breast tumor xenografts was associated with loss of tumorigenicity and extensive necrosis, which results in prolonged regression of tumor growth. "
4.	Prostatic Neoplasms (Prostate Cancer) 11/01/2009 - "By contrast, GO-201 had no effect against MUC1-negative LNCaP, CWR22Rv1, and MDA-PCa-2b prostate cancer cells. " 11/01/2009 - "Treatment of MUC1-positive DU145 and PC3 prostate cancer cells with GO-201, and not an altered version, resulted in inhibition of proliferation. "
5.	Lung Neoplasms (Lung Cancer) 01/01/2017 - "Further, suppression of MUC1 cellular activity with GO-201 enhanced EREG production in lung cancer cells, which in turn protected cancer cells from GO-201-induced cell death. "

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3.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
4.	Bleomycin (Blenoxane)