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3- hydroxyandrosta- 5,7- diene- 17- carboxylic acid

has antineoplastic activity; structure in first source

Also Known As:

17-COOH-7DA

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Androstanes: 11
      - Androstenes: 5
        Androstadienes: 1
        3-hydroxyandrosta-5,7-diene-17-carboxylic acid: 2

Experts

1.	Chen, Jianjun: 2 articles (08/2021 - 03/2010)
2.	Li, Wei: 2 articles (08/2021 - 03/2010)
3.	Chen, Jingxuan: 1 article (08/2021)
4.	Li, Ling: 1 article (08/2021)
5.	Liao, Wenzhen: 1 article (08/2021)
6.	Liu, Jin: 1 article (08/2021)
7.	Slominski, Andrzej T: 1 article (08/2021)
8.	Yuan, Sijie: 1 article (08/2021)
9.	Żmijewski, Michał A: 1 article (08/2021)
10.	Janjetovic, Zorica: 1 article (03/2010)

Related Diseases

1.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 08/05/2021 - "Discovery of novel 3-hydroxyandrosta-5,7-Diene-17-Carboxylic acid derivatives as anti-inflammatory bowel diseases (IBD) agents."
2.	Melanoma (Melanoma, Malignant) 03/01/2010 - "17-COOH-7DA also inhibited proliferation of normal human epidermal melanocytes and human and hamster melanoma lines, however, with lower potency than for keratinocytes. " 03/01/2010 - "17-COOH-7DA inhibited cell colony formation of human and hamster melanoma cells, and induced monocyte-like differentiation of human HL60 leukemia cells. "
3.	Leukemia 03/01/2010 - "Thus, the new steroidal 5,7-diene, 17-COOH-7DA, can serve as an inhibitor of proliferation of normal keratinocytes and normal and malignant melanocytes, as a condition-dependent regulator of fibroblast proliferation and a stimulator of leukemia cell differentiation." 03/01/2010 - "17-COOH-7DA inhibited cell colony formation of human and hamster melanoma cells, and induced monocyte-like differentiation of human HL60 leukemia cells. "