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CH 4986399

a selective estrogen receptor down-regulator; structure in first source

Also Known As:

CH-4986399; CH4986399

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Bridged-Ring Heterocyclic Compounds
  - Heterocyclic Bridged Bicyclo Compounds
    - CH 4986399: 1

Experts

1.	Kaiho, Shin-Ichi: 1 article (03/2010)
2.	Kanbe, Yoshitake: 1 article (03/2010)
3.	Morikawa, Kazumi: 1 article (03/2010)
4.	Nakamura, Ryo: 1 article (03/2010)
5.	Ohizumi, Iwao: 1 article (03/2010)
6.	Taniguchi, Kenji: 1 article (03/2010)
7.	Tsunenari, Toshiaki: 1 article (03/2010)
8.	Yamada-Okabe, Hisafumi: 1 article (03/2010)
9.	Yoneya, Takaaki: 1 article (03/2010)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 03/01/2010 - "We examined the oral antitumor activity and down-regulation of ER by CH4986399 in human breast cancer Br-10 and ZR-75-1 xenografts. " 03/01/2010 - "Thiochroman derivative CH4986399, a new nonsteroidal estrogen receptor down-regulator, is effective in breast cancer models." 03/01/2010 - "With a chemical structure different from both fulvestrant and tamoxifen, CH4986399, may help overcome drug resistance from the endocrine treatment sequence for breast cancer patients."
2.	Neoplasms (Cancer) 03/01/2010 - "In the ZR-75-1 xenografts, CH4986399 (100 mg/kg p.o.) strongly reduced tumor weight and ER content without agonistic activity. " 03/01/2010 - "In the Br-10 xenografts, CH4986399 (100 mg/kg p.o.) as well as fulvestrant (3 mg/body s.c.) strongly reduced tumor weight. "

Related Drugs and Biologics

1.	Estrogen Receptors
2.	Tamoxifen
3.	Fulvestrant (Faslodex)