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10,13- dimethyl- 17- (2- (6- sulfanylidene- 3H- purin- 9- yl)acetyl)- 1,2,6,7,8,9,11,12,14,15,16,17- dodecahydrocyclopenta(a)phenanthren- 3- one

has antineoplastic activity; structure in first source

Also Known As:

NSC 114792; NSC-114792; NSC114792

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Diterpenes: 1470
      - 10,13-dimethyl-17-(2-(6-sulfanylidene-3H-purin-9-yl)acetyl)-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta(a)phenanthren-3-one: 1
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - 10,13-dimethyl-17-(2-(6-sulfanylidene-3H-purin-9-yl)acetyl)-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta(a)phenanthren-3-one: 1

Experts

1.	Bach, Erika A: 1 article (02/2010)
2.	Baeg, Gyeong-Hun: 1 article (02/2010)
3.	Jayabose, Somasundaram: 1 article (02/2010)
4.	Jee, Jun-Goo: 1 article (02/2010)
5.	Kim, Byung-Hak: 1 article (02/2010)
6.	Kitamura, Daisuke: 1 article (02/2010)
7.	Sandoval, Claudio: 1 article (02/2010)
8.	Yin, Chang-Hong: 1 article (02/2010)

Related Diseases

1.

Neoplasms (Cancer)

02/11/2010 - "Finally, we showed that NSC114792 decreases cell viability by inducing apoptosis through down-regulating anti-apoptotic gene expression only in cancer cells harboring persistently-active JAK3. "
02/11/2010 - "Consistent with the specificity of NSC114792 for JAK3, it selectively inhibited persistently-activated JAK3, but failed to affect the activity of other JAK family members and other oncogenic kinases in various cancer cell lines. "

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