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threonyl- seryl- phenylalanyl- alanyl- glutamyl- tyrosyl- tryptophyl- asparagyl- leucyl- leucyl- seryl- proline

activates p53

Also Known As:

PMI peptide; TSFAEYWNLLSP; Thr-Ser-Phe-Ala-Glu-Tyr-Trp-Asn-Leu-Leu-Ser-Pro

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - threonyl-seryl-phenylalanyl-alanyl-glutamyl-tyrosyl-tryptophyl-asparagyl-leucyl-leucyl-seryl-proline: 2

Experts

1.	Ding, Wenzhou: 1 article (01/2021)
2.	Gao, Wen: 1 article (01/2021)
3.	Han, Guoyong: 1 article (01/2021)
4.	Shen, Hongbing: 1 article (01/2021)
5.	Tang, Jinhai: 1 article (01/2021)
6.	Tang, Qiyun: 1 article (01/2021)
7.	Wang, Xuehao: 1 article (01/2021)
8.	Wu, Jindao: 1 article (01/2021)
9.	You, Wei: 1 article (01/2021)
10.	Chi, Seung-Wook: 1 article (01/2014)

Related Diseases

1.

Neoplasms (Cancer)

01/17/2014 - "Finally, our structural comparison provided a molecular basis for how the same PMI peptide can bind to two distinct anti-cancer target proteins Bcl-XL and MDM2, which may have potential applications for multi-targeting cancer therapy. "
01/05/2021 - "The novel nanomedicine consisted of three components: (1) dual anti-cancer drugs, 10-hydroxycamptothecin (HCPT) and chlorambucil (CRB), whose targets are located in the cell nucleus, (2) a nuclear localizing dodecapeptide, PMI peptide (TSFAEYWNLLSP), which could activate p53 by binding with MDM2 and MDMX located in the cell nucleus, and (3) an efficient self-assembling tripeptide FFY. "

Related Drugs and Biologics

1.	threonyl- seryl- phenylalanyl- alanyl- glutamyl- tyrosyl- tryptophyl- asparagyl- leucyl- leucyl- seryl- proline
2.	Proteins (Proteins, Gene)
3.	Chlorambucil (Leukeran)
4.	homocamptothecin
5.	10-hydroxycamptothecin

Related Therapies and Procedures

1.	Therapeutics