|1.||Beyer, Christian: 1 article (07/2013)|
|2.||Distler, Oliver: 1 article (07/2013)|
|3.||Varga, John: 1 article (07/2013)|
|4.||Gelse, Kolja: 1 article (07/2013)|
|5.||Mallano, Tatjana: 1 article (07/2013)|
|6.||Schett, Georg: 1 article (07/2013)|
|7.||Distler, Alfiya: 1 article (07/2013)|
|8.||Lin, Neng Yu: 1 article (07/2013)|
|9.||Reichert, Helena: 1 article (07/2013)|
|10.||Palumbo-Zerr, Katrin: 1 article (07/2013)|
01/01/2012 - "Administration of PKF118-310 to tumor-bearing mice halted tumor growth in vivo. "
01/01/2012 - "Incubation of primary tumor cells in vitro with PKF118-310 eliminated their capacity to subsequently seed tumor growth after transplant into syngeneic mice. "
01/01/2012 - "Moreover, viable tumor cells harvested from PKF118-310 treated mice were unable to seed the growth of secondary tumors after transplant. "
07/01/2013 - "PKF118-310 and ICG-001 were effective in inhibiting TGF-β receptor I-driven fibrosis as assessed by the same outcome measures. "
07/01/2013 - "Blockade of canonical Wnt signalling by PKF118-310 and ICG-001 showed antifibrotic effects in different models of skin fibrosis. "
07/01/2013 - "We examined the antifibrotic effects of PKF118-310 and ICG-001, two novel inhibitors of downstream canonical Wnt signalling, in the models of prevention and treatment of bleomycin-induced dermal fibrosis as well as in experimental dermal fibrosis induced by adenoviral overexpression of a constitutively active transforming growth factor (TGF)-β receptor I. PKF118-310 and ICG-001 were well tolerated throughout all experiments. "
|3.||Osteosarcoma (Osteogenic Sarcoma)
12/01/2010 - "In this study, we tested the hypothesis that osteosarcoma progression may be delayed by disrupting the Wnt/β-catenin pathway using small molecule inhibitors such as curcumin and PKF118-310. "
12/01/2010 - "Our findings strongly suggest that curcumin and PKF118-310 have great therapeutic potential for the treatment of osteosarcoma."
12/01/2010 - "Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/β-catenin antagonists against human osteosarcoma cells."
12/01/2010 - "We next performed wound healing and Matrigel invasion assays and observed a dose-dependent decrease in osteosarcoma cell migration and invasion with curcumin and PKF118-310 treatment. "
12/01/2010 - "Effective inhibitions of the Wnt/β-catenin pathway by curcumin and PKF118-310 in osteosarcoma cells were shown by the suppression of both intrinsic and activated β-catenin/Tcf transcriptional activities using luciferase reporter assays. "
|3.||Transforming Growth Factors (Transforming Growth Factor)