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1- (4- chlorophenylhydrazono)- 1- (4- chlorophenylamino)- 3,3- dimethyl- 2- butanone

an S1P3 sphingosine receptor antagonist; structure in first source

Also Known As:

TY 52156; TY-52156; TY52156

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrazines: 379
  - Hydrazones: 500
    - 1-(4-chlorophenylhydrazono)-1-(4-chlorophenylamino)-3,3-dimethyl-2-butanone: 5

Experts

1.	Chen, Min: 1 article (01/2020)
2.	Chen, Su-Fang: 1 article (01/2020)
3.	Li, Zhi-Ying: 1 article (01/2020)
4.	Little, Mark A: 1 article (01/2020)
5.	Sun, Xiao-Jing: 1 article (01/2020)
6.	Wang, Chen: 1 article (01/2020)
7.	Wang, Luo-Yi: 1 article (01/2020)
8.	Zhao, Ming-Hui: 1 article (01/2020)
9.	Hasegawa, Takeshi: 1 article (04/2010)
10.	Hayashi, Kenji: 1 article (04/2010)

Related Diseases

1.	Vasculitis (Vasculitides) 01/01/2020 - "In the present study, we investigated the effects of three different S1P receptors modulators (FTY720, SEW2871 and TY52156) in a recognized rat model of experimental autoimmune vasculitis (EAV). "
2.	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 10/01/2023 - "Finally, we assessed S1PR3 inhibitor TY-52156 in T-ALL patient-derived xenografts (PDXs) mouse model. " 10/01/2023 - "We found that TY-52156 attenuated leukemia progression efficiently and extended the lifespan of S1PR3hi TAL1+ T-ALL xenografts. "
3.	Pulmonary Edema 01/01/2023 - "Compared with CLP mice treated with vehicle, CLP mice treated with the S1PR3 antagonist, TY52156, had aggravated pulmonary edema, increased bacterial loads in the lung, liver, spleen, and blood, and a higher seven-day mortality rate. "
4.	Pneumonia (Pneumonitis) 11/08/2023 - "TY-52156 effectively attenuated VILI-induced increases in bronchoalveolar lavage cell counts and protein concentration, suppressed the release of pro-inflammatory cytokines, and inhibited lung inflammation as assessed via a histological evaluation. "
5.	Leukemia 10/01/2023 - "We found that TY-52156 attenuated leukemia progression efficiently and extended the lifespan of S1PR3hi TAL1+ T-ALL xenografts. "

Related Drugs and Biologics

1.	Fingolimod Hydrochloride (FTY720)
2.	SEW2871
3.	Cytokines
4.	Proteins (Proteins, Gene)