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monocillin II

structure in first source

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Lactones: 1549
  - monocillin II: 2

Experts

1.	Ahmad, Aamir: 1 article (01/2022)
2.	Al Sharie, Ahmed H: 1 article (01/2022)
3.	Al Zu'bi, Yazan O: 1 article (01/2022)
4.	Alali, Feras Q: 1 article (01/2022)
5.	El-Elimat, Tamam: 1 article (01/2022)
6.	Kuttikrishnan, Shilpa: 1 article (01/2022)
7.	Oberlies, Nicholas H: 1 article (01/2022)
8.	Prabhu, Kirti S: 1 article (01/2022)
9.	Uddin, Shahab: 1 article (01/2022)
10.	Ruan, Yuanyuan: 1 article (02/2012)

Related Diseases

1.	Neoplasms (Cancer) 02/13/2012 - "Monocillin II, a trans-enone RAL without epoxy and conjugated dienone, was found to have higher activity in inhibiting tumor cell growth in both in vitro experiment and in vivo nude xenografted mice model than its analogue radicicol, an anticancer lead compound. " 01/01/2022 - "Following discovery of the selective Hsp90 inhibition activity of radicicol, the kinase inhibition activity of hypothemycin, monocillin II, 5Z-7-oxo-zeaenol, and L-783,277 RALs, and the nuclear factor kappa B (NF-κB) inhibition activity of the RAL zearalenone, have attracted great attention as potential therapeutics for cancer treatment. "
2.	Breast Neoplasms (Breast Cancer) 02/13/2012 - "These results suggest that monocillin II has potential therapeutic benefits in breast cancer prevention and intervention." 02/13/2012 - "Monocillin II inhibits human breast cancer growth partially by inhibiting MAPK pathways and CDK2 Thr160 phosphorylation." 02/13/2012 - "We demonstrated for the first time that monocillin II could arrest breast cancer cell cycle in G1 phase, which might partially be the result of its inhibition effect on the phosphorylation of the Thr160 residue of cyclin dependent kinase 2 (CDK2), a key enzyme in cell-cycle regulation. "

Related Drugs and Biologics

1.	monorden (radicicol)
2.	Cyclin-Dependent Kinase 2
3.	NF-kappa B (NF-kB)
4.	Zearalenone
5.	Phosphotransferases (Kinase)
6.	Enzymes
7.	7-oxozeanol
8.	L 783277
9.	hypothemycin

Related Therapies and Procedures

1.	Therapeutics