|1.||Murphy, Brian J: 1 article (03/2010)|
|2.||Zaveri, Nurulain T: 1 article (03/2010)|
|3.||Waleh, Nahid S: 1 article (03/2010)|
03/01/2010 - "Given the multifunctional inhibitory activity of TIMP-2 on tumor growth and invasion, the observed increase in TIMP-2 expression by SR13179 may play a central role in the anti-tumor and anti-invasive activity of this novel small molecule. "
03/01/2010 - "SR13179 also possesses potent anti-tumor activity in several tumor cell lines regardless of their hormone receptor, p53 or multi-drug resistance status. "
|2.||Breast Neoplasms (Breast Cancer)
03/01/2010 - "Increase in tissue inhibitor of metalloproteinase-2 (TIMP-2) levels and inhibition of MMP-2 activity in a metastatic breast cancer cell line by an anti-invasive small molecule SR13179."
03/01/2010 - "We report that a novel small molecule synthetic flavanoid SR13179, which inhibits the invasion of a highly metastatic human breast cancer cell line MCF-10CA1a through Matrigel, significantly increases protein and mRNA levels of TIMP-2 in a time- and dose-dependent manner. "
|1.||Tissue Inhibitor of Metalloproteinase-2
|2.||Messenger RNA (mRNA)