solithromycin

an antibacterial fluoroketolide; structure in first source

Also Known As:

(3AR,4R,7S,9R,10R,11R,13R,15R,15AR)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyl-10-trideoxy-(dimethylamino)-; CEM 101; CEM-101; OP 1068; OP-1068

Networked: 55 relevant articles (10 outcomes, 17 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Triazoles: 1533
      - solithromycin: 55
Organic Chemicals: 133
- Lactones: 1549
  - Macrolides: 4391
    - solithromycin: 55
  - Polyketides: 231
    - Macrolides: 4391
      - solithromycin: 55
Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Polyketides: 231
    - Macrolides: 4391
      - solithromycin: 55

Experts

1.	Fernandes, Prabhavathi: 16 articles (01/2020 - 02/2012)
2.	Cohen-Wolkowiez, Michael: 6 articles (01/2022 - 04/2016)
3.	Jamieson, Brian D: 6 articles (01/2018 - 06/2013)
4.	Hornik, Christoph P: 5 articles (01/2022 - 04/2016)
5.	Gonzalez, Daniel: 5 articles (01/2021 - 04/2016)
6.	Keedy, Kara: 5 articles (01/2018 - 04/2016)
7.	Farrell, David J: 5 articles (01/2016 - 04/2010)
8.	Jones, Ronald N: 5 articles (01/2016 - 04/2010)
9.	Castanheira, Mariana: 5 articles (01/2011 - 04/2010)
10.	Oldach, David: 4 articles (01/2019 - 06/2013)

Related Diseases

1.	Bacterial Pneumonia 01/01/2020 - "Solithromycin, a later generation ketolide, was effective in treating bacterial pneumonia, but it was not approved by the U.S. " 01/01/2021 - "Solithromycin has demonstrated efficacy in adults with community-acquired bacterial pneumonia and has also been investigated in pediatric patients. " 05/01/2019 - "Solithromycin monotherapy for treatment of community-acquired bacterial pneumonia: A meta-analysis of randomised controlled trials." 01/01/2019 - "These data provided dose selection support for solithromycin for clinical trials in patients with community-acquired bacterial pneumonia." 01/01/2022 - "Solithromycin in Children and Adolescents With Community-acquired Bacterial Pneumonia."
2.	Infections 01/01/2019 - "Using a neutropenic murine lung infection model, the objectives of this study were to identify the pharmacokinetic/pharmacodynamic (PK/PD) index most closely associated with efficacy and the magnitude of such indices associated with solithromycin efficacy against Streptococcus pneumoniae Plasma and epithelial lining fluid (ELF) samples for pharmacokinetics (PK) were collected serially over 24 hours from healthy mice administered single doses of solithromycin (0.625 to 40 mg/kg). " 12/01/2010 - "This contemporary surveillance study utilizing clinical isolates shows that solithromycin exhibits favorable in vitro potency and spectrum of activity against bacterial pathogens most frequently isolated in community-acquired respiratory tract (CA-RTI) and skin and skin structure infections (SSSI)." 01/01/2019 - "If insufficient duration of solithromycin exposure at the infection site in a subset of individuals was the reason for treatment failures, this might be adequately addressed with dose adjustment. " 01/01/2019 - "Pharmacokinetic/Pharmacodynamic Evaluation of Solithromycin against Streptococcus pneumoniae Using Data from a Neutropenic Murine Lung Infection Model." 01/01/2014 - "We have explored the maternal-amniotic-fetal pharmacokinetics of CEM-101 in a pregnant sheep model to assess its potential for treating intrauterine and antenatal infection. "
3.	Pneumonia (Pneumonitis) 04/01/2019 - "Our results suggest that solithromycin could be effective for pneumonia patients due to S. pneumoniae to reduce bacterial density in lung tissue." 04/01/2019 - "Solithromycin is a novel fluoroketolide developed to treat pneumonia. " 07/01/2017 - "These data support the continued development of solithromycin for the treatment of community-acquired pneumonia globally." 01/01/2016 - "The role of solithromycin in the management of bacterial community-acquired pneumonia." 06/01/2015 - "Solithromycin to treat community-acquired pneumonia?"
4.	Gonorrhea 04/01/2018 - "Solithromycin is also being investigated and has shown promise for the treatment of gonorrhea. " 10/01/2015 - "We conducted a phase 2 trial of 2 oral doses of solithromycin (1200 and 1000 mg) for treatment of uncomplicated gonorrhea. " 09/01/2013 - "The intracellular activity of solithromycin, combined with the low MICs to this agent, indicates that it may be an attractive option for gonorrhea treatment if clinical trials in development reveal that this drug can be used safely in adult indications, especially when multidrug-resistant clinical isolates are now emerging." 05/01/2012 - "Solithromycin might be an effective treatment option for gonorrhea." 05/01/2012 - "The activity of solithromycin was mainly superior to that of other antimicrobials (n = 10) currently or previously recommended for gonorrhea treatment. "
5.	Respiratory Tract Infections (Respiratory Tract Infection) 06/01/2010 - "The objective of this study was to assess the activity of CEM-101 and comparators against contemporary respiratory tract infection (RTI) isolates. " 07/01/2017 - "Gram-negative pathogens that cause community-acquired respiratory tract infections (Haemophilus influenzae and Moraxella catarrhalis) were inhibited by solithromycin isolated from worldwide locations (MIC90 2 and 0.25 µg/mL, respectively). " 07/01/2017 - "Surveillance of the activity of solithromycin (CEM-101) against bacteria from respiratory tract infections." 12/01/2016 - "Solithromycin is a novel fluoroketolide with high activity against bacteria associated with community-acquired respiratory tract infections as well as gonorrhea. " 01/01/2011 - "Solithromycin (CEM-101) is a novel fluoroketolide with high potency against Gram-positive and Gram-negative bacteria commonly associated with community-acquired respiratory tract infections and skin and skin-structure infections. "

Related Drugs and Biologics

1.	Fluoroquinolones
2.	Levofloxacin (Levaquin)
3.	Macrolides
4.	Anti-Bacterial Agents (Antibiotics)
5.	telithromycin (Ketek)
6.	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)
7.	Amino Acids
8.	tartaric acid (tartrate)
9.	Azithromycin (Zithromax)
10.	Erythromycin (Erycette)

Related Therapies and Procedures

1.	Therapeutics