1,4- diazabicyclo(3.2.2)nonan- 4- yl(5- (3- (trifluoromethyl)phenyl)furan- 2- yl)methanone

an alpha7 nicotinic acetylcholine receptor agonst; structure in first source

Also Known As:

A 793394; A-793394; A793394; NS 6740; NS-6740; NS6740

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Furans: 85
    - 1,4-diazabicyclo(3.2.2)nonan-4-yl(5-(3-(trifluoromethyl)phenyl)furan-2-yl)methanone: 3
- Bridged-Ring Heterocyclic Compounds
  - Heterocyclic Bridged Bicyclo Compounds
    - Azabicyclo Compounds
      - 1,4-diazabicyclo(3.2.2)nonan-4-yl(5-(3-(trifluoromethyl)phenyl)furan-2-yl)methanone: 3
Organic Chemicals: 133
- Aza Compounds: 3
  - Azabicyclo Compounds
    - 1,4-diazabicyclo(3.2.2)nonan-4-yl(5-(3-(trifluoromethyl)phenyl)furan-2-yl)methanone: 3

Experts

1.	Bagdas, Deniz: 2 articles (01/2018 - 04/2015)
2.	Damaj, M Imad: 2 articles (01/2018 - 04/2015)
3.	Kulkarni, Abhijit R: 2 articles (01/2018 - 04/2015)
4.	Papke, Roger L: 2 articles (01/2018 - 04/2015)
5.	Thakur, Ganesh A: 2 articles (01/2018 - 04/2015)
6.	Beaton, Graham: 1 article (01/2021)
7.	Gaidhani, Nikhil: 1 article (01/2021)
8.	Kem, William R: 1 article (01/2021)
9.	Tucci, Fabio C: 1 article (01/2021)
10.	Uteshev, Victor V: 1 article (01/2021)

Related Diseases

1.	Pain (Aches) 04/01/2015 - "In addition, NS6740 administration reversed pain-induced aversion, an important affective component of pain. " 04/01/2015 - "NS6740 was tested in several pain models after in vivo administration in the mouse. " 01/01/2018 - "Although GAT107 and NS6740 appear to stably induce different non-conducting states, both agents are effective treatment for inflammation and inflammatory pain models. " 01/01/2018 - "However, the similarity of NS6740 and GAT107 effects on inflammation and pain suggests that the different stable non-conducting states have common activity on signal transduction. " 04/01/2015 - "Although it had no effects in acute thermal pain, NS6740 induced significant dose- and time-dependent antinociceptive activity in formalin- and acetic acid-induced nociceptive behaviors as well as in the chronic constrictive nerve injury (CCI) model for neuropathic pain. "
2.	Inflammation (Inflammations) 01/01/2018 - "Although GAT107 and NS6740 appear to stably induce different non-conducting states, both agents are effective treatment for inflammation and inflammatory pain models. " 01/01/2018 - "However, the similarity of NS6740 and GAT107 effects on inflammation and pain suggests that the different stable non-conducting states have common activity on signal transduction. "
3.	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/01/2021 - "This hypothesis was tested using a transient middle cerebral artery occlusion (MCAO) model of acute ischaemic stroke, NS6740, a known selective non-ionotropic agonist of α7 nAChRs and 4OH-GTS-21, a partial α7 agonist. "
4.	Neuralgia (Stump Neuralgia) 04/01/2015 - "Although it had no effects in acute thermal pain, NS6740 induced significant dose- and time-dependent antinociceptive activity in formalin- and acetic acid-induced nociceptive behaviors as well as in the chronic constrictive nerve injury (CCI) model for neuropathic pain. "
5.	Brain Injuries (Brain Injury) 01/01/2021 - "4OH-GTS-21, used as a positive control, significantly reduced neurological deficits and brain injury after MCAO as compared to vehicle and NS6740. "

Related Drugs and Biologics

1.	4- (4- bromophenyl)- 3a,4,5,9b- tetrahydro- 3H- cyclopenta(c)quinoline- 8- sulfonamide
2.	Acetic Acid (Vinegar)
3.	Formaldehyde (Formol)
4.	3- (4- hydroxy- 2- methoxybenzylidene)anabaseine