|1.||Hu, Zhongyi: 5 articles (02/2016 - 01/2013)|
|2.||Lou, Hongxiang: 5 articles (02/2016 - 01/2013)|
|3.||Yuan, Huiqing: 5 articles (02/2016 - 01/2013)|
|4.||Lou, Hong-Xiang: 4 articles (12/2014 - 01/2012)|
|5.||Qu, Xian-Jun: 4 articles (12/2014 - 01/2012)|
|6.||Sun, Cui-Cui: 3 articles (12/2014 - 02/2012)|
|7.||Gao, Zu-Hua: 3 articles (12/2014 - 01/2012)|
|8.||Zhao, Cui-Rong: 3 articles (06/2012 - 01/2012)|
|9.||Xue, Xia: 3 articles (06/2012 - 09/2011)|
|10.||Liu, Hui-Ping: 3 articles (06/2012 - 01/2012)|
02/28/2013 - "In the present study, the effect of a novel derivative of riccardin D (RD-N) against cancer cell lines was investigated in vitro and in vivo. "
09/30/2011 - "In this combined in vitro and in vivo study, we examined the inhibitory effects of riccardin D on tumor angiogenesis and the subsequent effect of anticancer activity was evaluated. "
12/01/2014 - "Riccardin D, a liverwort-derived naturally occurring macrocyclic bisbibenzyl, has been found to exert anticancer effects in multiple cancer cell types. "
09/01/2013 - "Riccardin D (RD), a liverwort-derived naturally occurring macrocyclic bisbibenzyl, has been found to exert anticancer effects in multiple cancer cell types through apoptosis induction. "
06/01/2012 - "Riccardin D injection produced a 44.5% inhibition of cancer growth without apparent signs of toxicity to animals. "
|2.||Prostatic Neoplasms (Prostate Cancer)
02/01/2014 - "Induction of DNA damage and p21-dependent senescence by Riccardin D is a novel mechanism contributing to its growth suppression in prostate cancer cells in vitro and in vivo."
01/01/2013 - "Riccardin D Exerts Its Antitumor Activity by Inducing DNA Damage in PC-3 Prostate Cancer Cells In Vitro and In Vivo."
02/01/2014 - "Our previous studies had shown that Riccardin D (RD) exhibited cytotoxic effects by induction of apoptosis and inhibition of angiogenesis and topoisomerase II. Here, we reported that apoptosis is not the sole mechanism by which RD inhibits tumor cell growth because low concentrations of RD caused cellular senescence in prostate cancer (PCa) cells. "
02/01/2016 - "The objective of this study is to investigate the effect of bisbibenzyl compounds riccardin C (RC), marchantin M (MM), and riccardin D (RD) on androgen receptor (AR) in prostate cancer (PCa) cells. "
02/01/2012 - "We studied the effect of riccardin D, a macrocyclic bisbibenzyl, which was isolated from the Chinese liverwort plant, on human leukemia cells and the underlying molecular mechanism. "
02/01/2012 - "Riccardin D had a significant antiproliferative effect on human leukemia cell lines HL-60, K562 and its multidrug resistant (MDR) counterpart K562/A02 cells, but showed no effect on the topoisomerase-II-deficient HL-60/MX2 cells, as measured by the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay. "
02/01/2012 - "Riccardin D, a novel macrocyclic bisbibenzyl, induces apoptosis of human leukemia cells by targeting DNA topoisomerase II."
02/01/2012 - "After treatment with riccardin D, nuclear extracts of leukemia K562 and K562/A02 cells left the majority of pBR322 DNA in a supercoiled form. "
06/01/2012 - "Our previous study showed that riccardin D induced apoptosis of human leukemia cells by targeting DNA topoisomerase II (topo II). "
|4.||Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
|5.||Breast Neoplasms (Breast Cancer)
12/01/2014 - "In this study, we investigated the effect and mechanism of Riccardin D on human breast cancer. "
12/01/2014 - "The antitumour effects of Riccardin D were assessed by the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay and human breast cancer xenografts mice model. "
12/01/2014 - "Overall, these results demonstrate that Riccardin D may inhibit human breast cancer growth through suppression of telomerase activity. "
12/01/2014 - "Riccardin D, a macrocyclic bisbibenzy, inhibits human breast cancer growth through the suppression of telomerase activity."
|1.||Type II DNA Topoisomerases (Topoisomerase II)
|2.||trioctyl phosphine oxide (TOPO)
|3.||A-Form DNA (A-DNA)
|4.||Androgen Receptors (Androgen Receptor)
|6.||DNA (Deoxyribonucleic Acid)
|7.||Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
|8.||Telomerase (Telomerase Reverse Transcriptase)
|9.||RNA-Directed DNA Polymerase (Reverse Transcriptase)
|1.||Heterologous Transplantation (Xenotransplantation)