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2-benzo(1,3)dioxol-5-ylthiazole

has an anti-fibrotic effect; structure in first source

Also Known As:

CW 209292; CW-209292; CW209292

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazoles: 392
    - 2-benzo(1,3)dioxol-5-ylthiazole: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - 2-benzo(1,3)dioxol-5-ylthiazole: 1
  - Dioxoles
    - Benzodioxoles: 3
      - 2-benzo(1,3)dioxol-5-ylthiazole: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzodioxoles: 3
      - 2-benzo(1,3)dioxol-5-ylthiazole: 1

Experts

1.	Ha, Jong-Ryul: 1 article (08/2009)
2.	Kim, Dae-Hoon: 1 article (08/2009)
3.	Kim, Dae-Yong: 1 article (08/2009)
4.	Oh, Se-Woong: 1 article (08/2009)

Related Diseases

1.	Neoplasms (Cancer) 08/01/2009 - "Furthermore, tumor growth factor (TGF)-beta1 mRNA expression was increased in DMN-treated rats, whereas CW209292 treatment prevented these increases. "
2.	Inflammation (Inflammations) 08/01/2009 - "CW209292 also significantly reduced hepatic hydroxyproline content as well as hepatic fibrosis and inflammation in histological examination. "
3.	Fibrosis (Cirrhosis) 08/01/2009 - "CW209292 also significantly reduced hepatic hydroxyproline content as well as hepatic fibrosis and inflammation in histological examination. " 08/01/2009 - "These results suggest that CW209292 exhibits anti-fibrotic effects in Sprague Dawley rats with DMN-induced hepatic fibrosis by blocking the mRNA expression of TGF-beta1 and subsequent inhibition of the proliferation of hepatic stellate cells." 08/01/2009 - "Anti-fibrotic effects of a methylenedioxybenzene compound, CW209292 on dimethylnitrosamine-induced hepatic fibrosis in rats."

Related Drugs and Biologics

1.	Transforming Growth Factor beta1 (TGF beta 1)
2.	Intercellular Signaling Peptides and Proteins (Growth Factors)
3.	Messenger RNA (mRNA)
4.	Hydroxyproline (4 Hydroxyproline)
5.	Dimethylnitrosamine (Nitrosodimethylamine)
6.	1,3-benzodioxole