|1.||Jiang, Yimin: 2 articles (01/2013 - 01/2010)|
|2.||Ye, Jia: 2 articles (01/2013 - 01/2010)|
|3.||Sun, Qi: 2 articles (01/2013 - 01/2010)|
|4.||Li, Runtao: 2 articles (01/2013 - 01/2010)|
|5.||Zhang, Weiwei: 1 article (01/2013)|
|6.||Gao, Xiaoli: 1 article (01/2013)|
|7.||Zhao, Xia: 1 article (01/2010)|
|8.||Xiong, Yulan: 1 article (01/2010)|
01/01/2013 - "Anti-inflammation of spirocyclopiperazinium salt compound LXM-10 targeting α7 nAChR and M4 mAChR and inhibiting JAK2/STAT3 pathway in rats."
01/01/2013 - "In conclusion, the studies showed that intragastric administration of LXM-10 exerted significant anti-inflammation effects in acute and chronic models, which may be attribute to the activation of α7 nicotinic acetylcholine receptor and M4 muscarinic acetylcholine receptor, thereby inhibiting the JAK2/STAT3 signal pathway, and ultimately reducing the production of pro-inflammatory cytokines of TNF-α and IL-6. "
01/25/2010 - "We found that LXM-10 produced a significant, dose-dependent decrease in xylene- and carrageenin-induced edema. "
01/01/2013 - "The results showed that LXM-10 produced significant anti-inflammatory effects on carrageenan induced paw edema and complete Freund's adjuvant (CFA) induced arthritis, in which LXM-10 inhibited paw swelling in a dose- and time-dependent manner. "
|2.||Interleukin-6 (Interleukin 6)
|3.||Nicotinic Receptors (Nicotinic Acetylcholine Receptor)
|4.||Muscarinic Receptors (Muscarinic Acetylcholine Receptor)