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swietenine

hypoglycemic from Swietenia macrophylla seeds; structure in first source

Networked: 7 relevant articles (1 outcomes, 2 trials/studies)

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Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - Limonins: 143
        swietenine: 7

Experts

1.	Balijepalli, Madhu Katyayani: 1 article (07/2021)
2.	Chakravarthi, Srikumar: 1 article (07/2021)
3.	Mak, Kit-Kay: 1 article (07/2021)
4.	Pichika, Mallikarjuna Rao: 1 article (07/2021)
5.	Shiming, Zhang: 1 article (07/2021)
6.	Chen, Feng: 1 article (12/2020)
7.	Chu, Chunyan: 1 article (12/2020)
8.	Ding, Jingjing: 1 article (12/2020)
9.	Li, Kai: 1 article (12/2020)
10.	Liu, Shoubai: 1 article (12/2020)

Related Diseases

1.	Diabetic Nephropathies (Diabetic Nephropathy) 12/01/2022 - "Swietenine (Swi), isolated from Swietenia macrophylla King ameliorates inflammation and oxidative stress, and diabetic nephropathy has a close connection with them. " 12/01/2022 - "Natural swietenine attenuates diabetic nephropathy by regulating the NF-κB/NLRP3/Caspase-1 signaling pathways: In vivo and in vitro study."
2.	Inflammation (Inflammations) 12/01/2022 - "Swietenine (Swi), isolated from Swietenia macrophylla King ameliorates inflammation and oxidative stress, and diabetic nephropathy has a close connection with them. "
3.	Non-alcoholic Fatty Liver Disease 02/27/2023 - "Gene expression (qPCR) and immunohistochemical studies were performed to elucidate the mechanism of swietenine's effect in NAFLD. " 02/27/2023 - "It is concluded that swietenine shows beneficial effects in diabetes-induced NAFLD via inhibiting lipogenesis and activating the Nrf2 pathway." 02/27/2023 - "This study evaluated the effect of swietenine and its mechanisms in nonalcoholic fatty liver disease (NAFLD) in high-fat diet/streptozotocin-induced diabetic mice. " 02/27/2023 - "Swietenine Alleviates Nonalcoholic Fatty Liver Disease in Diabetic Mice via Lipogenesis Inhibition and Antioxidant Mechanisms."
4.	Hyperglycemia 02/27/2023 - "Our previous studies have reported the effect of swietenine (a major bioactive component of Swietenia macrophylla seeds) in reversing and potentiating the effect of metformin in hyperglycemia and hyperlipidaemia in diabetic rats. "
5.	Body Weight (Weight, Body) 07/01/2021 - "The activity of Swietenine was investigated at three different doses: 10, 20 and 40 mg/kg body weight (bw). " 02/27/2023 - "These increases were reversed by the oral administration of swietenine, 80 mg/kg body weight, on alternate days for eight weeks. " 06/01/2009 - "Oral administration of swietenine at 25 and 50 mg/kg body weight per day to diabetic rats was found to possess significant dose dependant hypoglycemic and hypolipidemic activity in type 2 diabetic rats."

Related Drugs and Biologics

1.	Caspase 1 (ICE Protease)
2.	Streptozocin (Streptozotocin)
3.	Metformin (Glucophage)
4.	Limonins
5.	Isoproterenol (Isoprenaline)
6.	Hypoglycemic Agents (Hypoglycemics)
7.	Chloroform (Trichloromethane)
8.	Antioxidants

Related Therapies and Procedures

1.	Oral Administration