|1.||Golding, Sarah E: 3 articles (06/2013 - 10/2009)|
|2.||Valerie, Kristoffer: 3 articles (06/2013 - 10/2009)|
|3.||O'Connor, Mark J: 3 articles (06/2013 - 10/2009)|
|4.||Rosenberg, Elizabeth: 3 articles (06/2013 - 10/2009)|
|5.||Baio, Gabriella: 2 articles (03/2015 - 07/2014)|
|6.||Vagge, Stefano: 2 articles (03/2015 - 07/2014)|
|7.||Marubbi, Daniela: 2 articles (03/2015 - 07/2014)|
|8.||Raso, Alessandro: 2 articles (03/2015 - 07/2014)|
|9.||Frosina, Guido: 2 articles (03/2015 - 07/2014)|
|10.||Mascelli, Samantha: 2 articles (03/2015 - 07/2014)|
06/15/2013 - "Importantly, we show that glioma with mutant p53 is much more sensitive to KU-60019 radiosensitization than genetically matched wild-type glioma. "
03/15/2012 - "In addition, without radiation, KU-60019 with or without TMZ reduced glioma cell growth but had no significant effect on the survival of human embryonic stem cell (hESC)-derived astrocytes. "
10/01/2009 - "Altogether, KU-60019 inhibits the DNA damage response, reduces AKT phosphorylation and prosurvival signaling, inhibits migration and invasion, and effectively radiosensitizes human glioma cells."
10/01/2009 - "We also show that KU-60019 inhibits glioma cell migration and invasion in vitro, suggesting that glioma growth and motility might be controlled by ATM via AKT. "
10/01/2009 - "As expected, KU-60019 is a highly effective radiosensitizer of human glioma cells. "
07/15/2014 - "Taken together, these findings suggest that GIC-driven tumors with low expression of TP53 and high expression of PI3K might be effectively and safely radiosensitized by KU-60019. "
07/15/2014 - "Herein, we report the experimental conditions to overcome GIC radioresistance in vitro using the specific ATM inhibitor KU-60019, two major determinants of the tumor response to this drug and the absence of toxicity of this treatment in vitro and in vivo. "
06/01/2015 - "Lastly, the ATM inhibitor KU-60019 was specifically toxic to PTEN mutant cancer cells in tumor xenografts and reversible by reintroduction of wild-type PTEN. "
03/15/2015 - "Pharmacokinetics, pharmacodynamics and efficacy on pediatric tumors of the glioma radiosensitizer KU60019."
06/15/2013 - "Human glioma cells expressing reporter genes for monitoring tumor growth and dispersal were grown intracranially, and KU-60019 was administered intratumorally by convection-enhanced delivery or osmotic pump. "
|3.||Glioblastoma (Glioblastoma Multiforme)
03/15/2015 - "We have recently reported that glioblastoma (GB)-initiating cells (GIC) with low expression and/or mutation of TP53 and high expression of PI3K ("responder" genetic profile) can be effectively and safely radiosensitized by the ATM inhibitor KU60019. "
07/15/2014 - "Predictability, efficacy and safety of radiosensitization of glioblastoma-initiating cells by the ATM inhibitor KU-60019."
03/15/2012 - "Colony-forming radiosurvival showed that continuous exposure to nanomolar concentrations of KU-60019 effectively radiosensitized glioblastoma cell lines. "
03/15/2012 - "The second generation ATMi analog KU-60019 provided quick, reversible and complete inhibition of the DDR at sub-micromolar concentrations in human glioblastoma cells. "
|5.||2- morpholin- 4- yl- 6- thianthren- 1- yl- pyran- 4- one
|1.||Heterologous Transplantation (Xenotransplantation)