2- ((1H- benzo(d)(1,2,3)triazol- 5- ylamino)methyl)- 4,6- dichlorophenol

interferes with the interaction between nNOS and PSD95;structure in first source

Also Known As:

IC 87201; IC-87201; IC87201

Networked: 7 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Chlorophenols: 95
        2-((1H-benzo(d)(1,2,3)triazol-5-ylamino)methyl)-4,6-dichlorophenol: 7
        Chlorobenzenes: 5
        Chlorophenols: 95
        2-((1H-benzo(d)(1,2,3)triazol-5-ylamino)methyl)-4,6-dichlorophenol: 7
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Triazoles: 1533
      - 2-((1H-benzo(d)(1,2,3)triazol-5-ylamino)methyl)-4,6-dichlorophenol: 7

Experts

1.	Hohmann, Andrea G: 3 articles (01/2017 - 10/2015)
2.	Kulkarni, Pushkar M: 3 articles (01/2017 - 10/2015)
3.	Lai, Yvonne Y: 3 articles (01/2017 - 10/2015)
4.	Thakur, Ganesh A: 3 articles (01/2017 - 10/2015)
5.	Lee, Wan-Hung: 2 articles (01/2017 - 10/2015)
6.	Xu, Zhili: 2 articles (05/2016 - 10/2015)
7.	Beitz, Alvin J: 1 article (11/2019)
8.	Choi, Sheu-Ran: 1 article (11/2019)
9.	Han, Ho-Jae: 1 article (11/2019)
10.	Lee, Jang-Hern: 1 article (11/2019)

Related Diseases

1.	Pain (Aches) 01/01/2017 - "IC87201 and ZL006, but not ZL007, suppressed phase 2 of formalin-evoked pain behavior and decreased the number of formalin-induced Fos-like immunoreactive cells in spinal dorsal horn regions associated with nociceptive processing. " 07/16/2015 - "ZL006 and IC87201 have been presented as efficient inhibitors of the nNOS/PSD-95 protein-protein interaction and shown great promise in cellular experiments and animal models of ischemic stroke and pain. " 10/01/2015 - "IC87201 and ZL006 preferentially suppressed phase 2A pain behavior in the formalin test and suppressed allodynia induced by intraplantar complete Freund's adjuvant administration. "
2.	Ischemic Stroke 07/16/2015 - "ZL006 and IC87201 have been presented as efficient inhibitors of the nNOS/PSD-95 protein-protein interaction and shown great promise in cellular experiments and animal models of ischemic stroke and pain. "
3.	Hyperalgesia 11/01/2019 - "IC87201 administration on post-operative days 0-3 also attenuated the CCI-induced development of mechanical allodynia (MA) and PKC-dependent (Ser896) pGluN1. " 09/01/2009 - "Intrathecal administration of IC87201 and tat-nNOS also reversed mechanical allodynia induced by chronic constriction of the sciatic nerve. " 10/01/2015 - "Finally, MK-801 produced hyperalgesia in the tail-flick test whereas IC87201 and ZL006 did not alter basal nociceptive thresholds. " 10/01/2015 - "IC87201 and ZL006 suppressed mechanical and cold allodynia induced by the chemotherapeutic agent paclitaxel (ED50s: 2.47 and 0.93 mg/kg i.p. " 10/01/2015 - "IC87201 and ZL006 preferentially suppressed phase 2A pain behavior in the formalin test and suppressed allodynia induced by intraplantar complete Freund's adjuvant administration. "
4.	Cognitive Dysfunction 05/15/2016 - "We also hypothesized that PSD95-nNOS inhibitors (IC87201 and ZL006) would lack the profile of cognitive impairment associated with global NMDAR antagonists. "
5.	Parkinson Disease (Parkinson's Disease) 12/01/2014 - "Here, small-molecule inhibitors of the PSD-95/nNOS interaction, IC87201 and ZL006 were tested for neuroprotective effects in an in vitro Parkinson's disease (PD) model. "

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