|1.||Higashi, Kiyoshi: 4 articles (12/2015 - 11/2009)|
|2.||Inagaki, Yutaka: 3 articles (12/2015 - 02/2011)|
|3.||Sumiyoshi, Hideaki: 2 articles (12/2015 - 06/2014)|
|4.||Tomigahara, Yoshitaka: 2 articles (02/2011 - 11/2009)|
|5.||Kaneko, Hideo: 2 articles (02/2011 - 11/2009)|
|6.||Hirano, Ken-Ichi: 1 article (12/2015)|
|7.||Imai, Jin: 1 article (12/2015)|
|8.||Hozumi, Katsuto: 1 article (12/2015)|
|9.||Abe, Jun: 1 article (12/2015)|
|10.||Yazawa, Masaki: 1 article (12/2015)|
12/25/2015 - "We have previously shown that the administration of a small compound, HSc025, which promotes the nuclear translocation of YB-1 as a downstream effector of IFN-γ and antagonizes TGF-β/Smad signaling, improves fibrosis in several murine tissues. "
02/11/2011 - "Here, we presented evidence as to the mechanism by which HSc025 stimulates nuclear translocation of YB-1 and the pharmacological effects of HSc025 on a murine model of hepatic fibrosis. "
12/25/2015 - "In this study, we evaluated the anti-fibrotic effect of HSc025 on colorectal fibrosis in TNBS-induced murine chronic colitis. "
12/25/2015 - "Daily oral administration of HSc025 (3, 15 and 75 mg/kg) suppressed collagen production and decreased the severity of colorectal fibrosis in a dose-dependent manner. "
02/11/2011 - "Oral administration of HSc025 to mice with carbon tetrachloride-induced hepatic fibrosis improved liver injury as well as the degree of hepatic fibrosis. "
|3.||Pulmonary Fibrosis (Hamman Rich Syndrome)
02/11/2011 - "More recently, we have demonstrated that the novel small compound HSc025 promotes nuclear translocation of YB-1, resulting in the improvement of skin and pulmonary fibrosis. "
11/01/2009 - "These results demonstrate that HSc025 is a novel inhibitor of TGFbeta/Smad signaling, resulting in the improvement of skin and pulmonary fibrosis. "
11/01/2009 - "HSc025 (15 mg/kg/day for 14 days) was administered orally to tight skin mice and to mice with bleomycin-induced pulmonary fibrosis. "
|4.||Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
|5.||Wounds and Injuries (Trauma)
|2.||Carbon Tetrachloride (Tetrachloromethane)
|3.||Y-Box-Binding Protein 1
|4.||Transforming Growth Factor beta (TGF-beta)