fatostatin

01/01/2020 - "Previous studies have shown that fatostatin has an anti-tumor effect in some cancers. "
04/01/2014 - "In the present study, we evaluated the anti-prostate tumor activity of a novel SREBP inhibitor, fatostatin. "
12/01/2020 - "Furthermore, treatment with the SREBP1c inhibitor fatostatin dampened the spontaneous formation of tumors in liver-specific Zhx2 knockout mice. "
12/18/2019 - "Further investigation is warranted for the clinical use of fatostatin for the treatment of esophageal malignancy."
12/18/2019 - "Mice treated with fatostatin showed a significantly lower tumor burden and better survival rate as compared to their control counterparts. "

01/01/2020 - "Fatostatin may have a promising clinical use for ER-positive breast cancer patients."
01/01/2020 - "The main objective of this study was to investigate fatostatin, which was found to sensitize breast cancer to the antitumour effect of tamoxifen both in vitro and in vivo. "
01/01/2022 - "Erratum: Fatostatin in Combination with Tamoxifen Induces Synergistic Inhibition in ER-Positive Breast Cancer [Corrigendum]."
01/01/2020 - "Fatostatin could induce ER degradation by K48-linked polyubiquitination, which was the key mechanism contributing to tamoxifen inhibition of PI3K-AKT-mTOR signalling in breast cancer. "
01/01/2020 - "Fatostatin in Combination with Tamoxifen Induces Synergistic Inhibition in ER-Positive Breast Cancer."

03/01/2023 - "SREBP and fatostatin are suggested as a promising target-therapeutic agent pair for drug-resistant glioblastoma."
01/01/2023 - "In our study, through transcriptome sequencing, in vivo experiments, and in vitro experiments, we found that fatostatin induces ferroptosis by inhibiting the AKT/mTORC1/GPX4 signaling pathway in glioblastoma. "
01/01/2023 - "Fatostatin induces ferroptosis through inhibition of the AKT/mTORC1/GPX4 signaling pathway in glioblastoma."
12/01/2016 - "Thus Fatostatin's ability to inhibit SREBP activity and cell division could prove beneficial in treating aggressive types of cancers such as glioblastomas that have elevated lipid metabolism and fast proliferation rates and often develop resistance to current anticancer therapies."

01/01/2022 - "Fatostatin ameliorates inflammation without affecting cell viability."
01/01/2022 - "Fatostatin is a small molecule that inhibits the maturation and function of SREBP, and its role in regulating inflammation is poorly understood. "

04/01/2018 - "The main aim of the present study was to investigate the effects and mechanism of fatostatin in endometrial carcinoma (EC). "
01/01/2021 - "Our results highlight the important role of SREBP1 in progesterone resistance and suggest that the use of Fatostatin to target SREBP1 may represent a new method to solve progesterone resistance in patients with endometrial cancer."
01/01/2021 - "Fatostatin reverses progesterone resistance by inhibiting the SREBP1-NF-κB pathway in endometrial carcinoma."
01/01/2020 - "Our results showed that fatostatin inhibited the growth and proliferation of human endometrial carcinoma cells, changed their cell cycle and induced apoptosis. "
01/01/2020 - "The growth of endometrial carcinoma xenografts was measured to confirm the effect of fatostatin in vivo. "