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WAY-262611

a wingless beta-catenin agonist; structure in first source

Also Known As:

(1-(4-(naphthalen-2-yl)pyrimidin-2-yl)piperidin-4-yl)methanamine; NPP-methanamine

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        WAY-262611: 3
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - WAY-262611: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - WAY-262611: 3
  - Piperidines: 17
    - WAY-262611: 3

Experts

1.	Wang, Jie: 1 article (06/2022)
2.	Xie, Huan: 1 article (06/2022)
3.	Arango, Diego: 1 article (11/2021)
4.	Gallego, Soledad: 1 article (11/2021)
5.	Gallo-Oller, Gabriel: 1 article (11/2021)
6.	Giralt, Irina: 1 article (11/2021)
7.	Hladun, Raquel: 1 article (11/2021)
8.	Magdaleno, Ainara: 1 article (11/2021)
9.	Moreno, Lucas: 1 article (11/2021)
10.	Navarro, Natalia: 1 article (11/2021)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2023 - "In addition, DKK1 inhibition by WAY-262611 reverses the suppressive tumor immune microenvironment (TIME) and upregulates NKG2DL expression levels in both GC cell lines and GC tissues from a xenograft NCG mouse model. " 11/29/2021 - "In addition, WAY-262611 was able to impair survival of tumor cells in vivo. "
2.	Lung Neoplasms (Lung Cancer) 06/01/2022 - "The results demonstrated that WAY-262611 potentiated lung cancer cell viability, invasion, and migration, but inhibited cell apoptosis. " 06/01/2022 - "Next, a β-catenin-specific agonist WAY-262611 was delivered into the H1299 and H460 cells to assess the effects of the Wnt/β-catenin pathway on lung cancer cellular processes. "

Related Drugs and Biologics

1.	Catenins