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Org 26576

AMPA receptor potentiator

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Isoxazoles: 155
      - alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid: 1158
        Org 26576: 5

Experts

1.	Shahid, Mohammed: 4 articles (12/2012 - 08/2005)
2.	Schipper, Jacques: 3 articles (12/2012 - 12/2011)
3.	Bursi, Roberta: 2 articles (12/2012 - 12/2011)
4.	Dogterom, Peter: 2 articles (12/2012 - 12/2011)
5.	Nations, Kari R: 2 articles (12/2012 - 12/2011)
6.	Adler, Lenard A: 1 article (12/2012)
7.	Cazorla, Pilar: 1 article (12/2012)
8.	Ereshefsky, Larry: 1 article (12/2012)
9.	Gertsik, Lev: 1 article (12/2012)
10.	Greenwald, Scott: 1 article (12/2012)

Related Diseases

1.	Major Depressive Disorder (Major Depressive Disorders) 12/01/2012 - "Examination of Org 26576, an AMPA receptor positive allosteric modulator, in patients diagnosed with major depressive disorder: an exploratory, randomized, double-blind, placebo-controlled trial."
2.	Schizophrenia (Dementia Praecox) 08/01/2005 - "These data demonstrate that both Org 26576 and Org 24448 produce dose-dependent AMPA receptor mediated increases in LCGU and provide an anatomical basis suggestive that these drugs may be of use in the treatment of conditions such as depression or schizophrenia." 05/01/2012 - "The α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor positive allosteric modulators (AMPA-PAMs), Org 24448 and Org 26576, and the glycine transporter-1 (GlyT-1) inhibitor Org 25935 are developed for treatment of schizophrenia. "
3.	Mental Disorders (Mental Disorder) 12/01/2011 - "The α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor potentiator Org 26576 represents an interesting pharmacological tool to evaluate the utility of glutamatergic enhancement towards the treatment of psychiatric disorders. "
4.	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 12/01/2012 - "Org 26576 (100 mg b.i.d.) was superior to placebo in treating symptoms of adult ADHD subjects. " 12/01/2012 - "A translational approach to evaluate the efficacy and safety of the novel AMPA receptor positive allosteric modulator org 26576 in adult attention-deficit/hyperactivity disorder."

Related Drugs and Biologics

1.	AMPA Receptors (AMPA Receptor)
2.	1-(benzofurazan-5-ylcarbonyl)piperidine
3.	alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)
4.	Glycine (Aminoacetic Acid)
5.	Acids
6.	N- methyl- N- (6- methoxy- 1- phenyl- 1,2,3,4- tetrahydronaphthalen- 2- ylmethyl)aminomethylcarboxylic acid
7.	propionic acid (potassium propionate)