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3-(2-(aminomethyl)phenyl)-8-(bis(2 chlorophenyl)methyl)-8-azabicyclo (3.2.1)octan-3-ol

a NOP receptor agonist; structure in first source

Also Known As:

SCH 225288; SCH-225288; SCH225288

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Aza Compounds: 3
  - Azabicyclo Compounds
    - Tropanes: 1
      - 3-(2-(aminomethyl)phenyl)-8-(bis(2 chlorophenyl)methyl)-8-azabicyclo (3.2.1)octan-3-ol: 1
Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Tropanes: 1
    - 3-(2-(aminomethyl)phenyl)-8-(bis(2 chlorophenyl)methyl)-8-azabicyclo (3.2.1)octan-3-ol: 1
- Bridged-Ring Heterocyclic Compounds
  - Tropanes: 1
    - 3-(2-(aminomethyl)phenyl)-8-(bis(2 chlorophenyl)methyl)-8-azabicyclo (3.2.1)octan-3-ol: 1
  - Heterocyclic Bridged Bicyclo Compounds
    - Azabicyclo Compounds
      - Tropanes: 1
        3-(2-(aminomethyl)phenyl)-8-(bis(2 chlorophenyl)methyl)-8-azabicyclo (3.2.1)octan-3-ol: 1

Experts

1.	Bolser, Donald C: 1 article (01/2009)
2.	Erickson, Christine H: 1 article (01/2009)
3.	Erskine, Jason: 1 article (01/2009)
4.	Fawzi, Ahmad B: 1 article (01/2009)
5.	Fernandez, Xiomara: 1 article (01/2009)
6.	Hey, John A: 1 article (01/2009)
7.	Ho, Ginny D: 1 article (01/2009)
8.	Jayappa, Huchappa: 1 article (01/2009)
9.	Lehr, Craig: 1 article (01/2009)
10.	McLeod, Robbie L: 1 article (01/2009)

Related Diseases

1.

01/01/2009 - "Similarly, SCH 225288 (0.001-0.3 mg/kg) administered intra-arterially also diminished cough number and abdominal EMG amplitudes. "
01/01/2009 - "SCH 225288 (0.03-3.0 mg/kg, i.v.) inhibited both cough number and abdominal EMG amplitudes. "
01/01/2009 - "In the anesthetized cat, we evaluated the effects of SCH 225288 given either intravenously or via the intravertebral artery against the increases in cough number and respiratory expiratory and inspiratory muscle (rectus abdominis and parasternal) electromyographic (EMG) activities due to perturbations of the intrathoracic trachea. "
01/01/2009 - "SCH 225288 is a nonpeptide, orally active NOP agonist that may provide the foundation for the development of novel treatments for cough. "
01/01/2009 - "Taken together, the present data show that SCH 225288 is a potent and effective antitussive agent in animal models of cough. "

Related Drugs and Biologics

1.	Irritants (Vesicants)
2.	Capsaicin (Zostrix)
3.	Butorphanol (BC 2627)
4.	Antitussive Agents (Antitussives)

Related Therapies and Procedures

1.	Oral Administration