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STA-1474

antineoplastic agent

Also Known As:

5-Hydroxy-2-isopropyl-4-(4-(1-methyl-1H-indol-5-yl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)phenyl dihydrogen phosphate

Networked: 4 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Triazoles: 1533
      - STA-1474: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - STA-1474: 4

Experts

1.	London, Cheryl A: 4 articles (12/2018 - 12/2009)
2.	Bear, Misty D: 3 articles (12/2018 - 12/2009)
3.	Barsoum, James: 2 articles (01/2011 - 12/2009)
4.	Foley, Kevin P: 2 articles (01/2011 - 12/2009)
5.	Ying, Weiwen: 2 articles (01/2011 - 12/2009)
6.	Acquaviva, Jaime: 1 article (12/2018)
7.	Bechtel, Sandra A: 1 article (12/2018)
8.	Bernabe, Louis Feo: 1 article (12/2018)
9.	Gardner, Heather L: 1 article (12/2018)
10.	Ogawa, Luisa Shin: 1 article (12/2018)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2011 - "The purpose of the following study was to extend these observations and investigate the safety and efficacy of STA-1474 in dogs with spontaneous tumors. " 01/01/2011 - "This study provides evidence that STA-1474 exhibits biologic activity in a relevant large animal model of cancer. " 01/01/2011 - "This was a Phase 1 trial in which dogs with spontaneous tumors received STA-1474 under one of three different dosing schemes. " 01/01/2015 - "Treatment of tumor-stromal fibroblasts with STA-1474 resulted in a dose-dependent decrease in their relative cell viability with a low IC50 of 0.28 μM. " 01/01/2011 - "Given the similarities of canine and human cancers with respect to tumor biology and HSP90 activation, it is likely that STA-1474 and ganetespib will demonstrate comparable anti-cancer activity in human patients."
2.	Osteosarcoma (Osteogenic Sarcoma) 12/15/2009 - "The novel HSP90 inhibitor STA-1474 exhibits biologic activity against osteosarcoma cell lines."
3.	Lung Neoplasms (Lung Cancer) 01/01/2015 - "As significant decreases in relative cell viability can be achieved with nanomolar concentrations of STA-1474, investigation into the clinical efficacy of this drug in canine lung cancer patients is warranted." 01/01/2015 - "We investigated the activity of STA-1474, a HSP90 inhibitor, in two canine lung cancer cell lines, BACA and CLAC. "

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