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A-839977

a selective P2X7 receptor antagonist, analgesic; structure in first source

Also Known As:

1-(2,3-dichlorophenyl)-N-(2-(pyridin-2- yloxy)benzyl)-1H-tetrazol-5-amine

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Tetrazoles: 14
      - A-839977: 2
  - Pyridines: 88
    - A-839977: 2

Experts

1.	Cao, Chujin: 1 article (05/2022)
2.	Chu, Xiaoxin: 1 article (05/2022)
3.	Deng, Xuan: 1 article (05/2022)
4.	Guo, Jing: 1 article (05/2022)
5.	Hong, Yu: 1 article (05/2022)
6.	Hu, Bin: 1 article (05/2022)
7.	Li, Yinzheng: 1 article (05/2022)
8.	Pei, Guangchang: 1 article (05/2022)
9.	Shi, Mengxia: 1 article (05/2022)
10.	Wang, Meng: 1 article (05/2022)

Related Diseases

1.	Pain (Aches) 12/01/2009 - "A-839977 also produced robust antihyperalgesia in the CFA model of inflammatory pain in wild-type mice (ED50=40 micromol/kg, i.p.), but the antihyperalgesic effects of A-839977 were completely absent in IL-1alphabeta knockout mice. "
2.	Hyperalgesia 12/01/2009 - "Systemic administration of A-839977 dose-dependently reduced thermal hyperalgesia produced by intraplantar administration of complete Freund's adjuvant (CFA) (ED50=100 micromol/kg, i.p.) in rats. "
3.	Fibrosis (Cirrhosis) 01/01/2022 - "Further, we found that GAP 26 (a Cx43 hemichannel inhibitor) and A-839977 (an inhibitor of the pyroptosis receptor) alleviated UUO-induced fibrosis, while BzATP (the agonist of pyroptosis receptor) exacerbated fibrosis. "

Related Drugs and Biologics

1.	Connexin 43 (Connexin43)
2.	Freund's Adjuvant
3.	3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate