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VU 0155041

an mGluR4 agonist

Also Known As:

VU-0155041; VU0155041

Networked: 4 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Conn, P Jeffrey: 2 articles (09/2009 - 11/2008)
2.	Johnson, Kari A: 2 articles (09/2009 - 11/2008)
3.	Lindsley, Craig W: 2 articles (09/2009 - 11/2008)
4.	Niswender, Colleen M: 2 articles (09/2009 - 11/2008)
5.	Williams, Richard: 2 articles (09/2009 - 11/2008)
6.	Chen, Xinlin: 1 article (01/2019)
7.	He, Dalin: 1 article (01/2019)
8.	Liu, Yingfei: 1 article (01/2019)
9.	Liu, Yong: 1 article (01/2019)
10.	Lu, Haixia: 1 article (01/2019)

Related Diseases

1.	Urinary Bladder Neoplasms (Bladder Cancer) 01/01/2019 - "We further confirmed that the activation of mGluR4 by VU0155041, an mGluR4-specific agonist, decreased cyclic adenosine monophosphate (cAMP) concentration and cell viability, promoted apoptosis and inhibited proliferation in bladder cancer cells, whereas MSOP (group III mGluR antagonist) or mGluR4 knockdown eliminated the effects of mGluR4 activity. "
2.	Neuralgia (Stump Neuralgia) 03/30/2011 - "In this study, we have shown that spinal administration of metabotropic GluRs (mGluR4)-positive allosteric modulator (VU0155041) dose dependently attenuated hyperalgesia in neuropathic pain model rats, whereas that of mGluR7-positive allosteric modulator (AMN082) did not. "
3.	Hyperalgesia 03/30/2011 - "In this study, we have shown that spinal administration of metabotropic GluRs (mGluR4)-positive allosteric modulator (VU0155041) dose dependently attenuated hyperalgesia in neuropathic pain model rats, whereas that of mGluR7-positive allosteric modulator (AMN082) did not. "
4.	Parkinson Disease (Parkinson's Disease) 09/01/2009 - "This Letter describes the synthesis and SAR of the novel positive allosteric modulator, VU0155041, a compound that has shown in vivo efficacy in rodent models of Parkinson's disease. "
5.	Catalepsy 11/01/2008 - "VU0155041 was soluble in an aqueous vehicle, and intracerebroventricular administration of 31 to 316 nmol of VU0155041 dose-dependently decreased haloperidol-induced catalepsy and reserpine-induced akinesia in rats. "

Related Drugs and Biologics

1.	Adenosine Monophosphate (AMP)
2.	methylserine phosphate (MSOP)
3.	metabotropic glutamate receptor 4
4.	N,N'-dibenzhydrylethane-1,2-diamine dihydrochloride
5.	Reserpine (Serpasil)
6.	Haloperidol (Haldol)