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PD 407824

Also Known As:

PD-407824; PD407824

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Carbazoles: 32
        PD 407824: 5
  - 3-Ring Heterocyclic Compounds
    - Carbazoles: 32
      - PD 407824: 5

Experts

1.	Chen, Andy: 2 articles (09/2018 - 01/2018)
2.	Li, Bai-Yan: 2 articles (09/2018 - 01/2018)
3.	Liu, Shengzhi: 2 articles (09/2018 - 01/2018)
4.	Yokota, Hiroki: 2 articles (09/2018 - 01/2018)
5.	Arora, Shilpi: 2 articles (09/2010 - 06/2009)
6.	Azorsa, David O: 2 articles (09/2010 - 06/2009)
7.	Basu, Gargi D: 2 articles (09/2010 - 06/2009)
8.	Bisanz, Kristen M: 2 articles (09/2010 - 06/2009)
9.	Choudhary, Ashish: 2 articles (09/2010 - 06/2009)
10.	Adachi, Takanori: 1 article (09/2021)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2018 - "Collectively, this FE study supports the notion that mechanical weakening of the femur was observed in the tumor-invaded trabecular bone, and chemical agents such as PD407824 may potentially assist in preventing bone loss and bone fracture." 09/01/2018 - "While a Chk1 inhibitor, PD407824, suppressed the proliferation of tumor cells and the differentiation of pre-osteoclasts, its effect on gene expression in osteoblasts was markedly different compared with AZD7762. "
2.	Bone Fractures (Bone Fracture) 01/01/2018 - "Collectively, this FE study supports the notion that mechanical weakening of the femur was observed in the tumor-invaded trabecular bone, and chemical agents such as PD407824 may potentially assist in preventing bone loss and bone fracture."
3.	Pancreatic Neoplasms (Pancreatic Cancer) 06/11/2009 - "Results showed that treatment of MIA PaCa-2 cells with either of the CHK1 inhibitors SB 218078 or PD 407824 led to sensitization of the pancreatic cancer cells to gemcitabine. "
4.	Ovarian Neoplasms (Ovarian Cancer) 09/01/2010 - "Results showed that treatment of SKOV3 and OVCAR3 cells with CHK1 inhibitor PD 407824 led to sensitization of ovarian cancer cells to cisplatin. "
5.	Breast Neoplasms (Breast Cancer) 09/13/2021 - "Here, we addressed this question by treating the human breast cancer cell line MDA-MB-231 (in vitro) and mouse mammary tumor cell line 4 T1 (in vitro and in vivo) with γ-irradiation and the Chk1 inhibitor PD407824. "

Related Drugs and Biologics

1.	Cisplatin (Platino)
2.	Gemcitabine
3.	3- (carbamoylamino)- 5- (3- fluorophenyl)- N- (3- piperidyl)thiophene- 2- carboxamide
4.	SB 218078