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N- ((6- (methyloxy)- 4'- (trifluoromethyl)- 3- biphenylyl)methyl)- 1- phenylethanamine

a calcimimetic

Also Known As:

AMG 641; AMG-641; AMG641

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Ethylamines: 5
    - Phenethylamines: 28
      - N-((6-(methyloxy)-4'-(trifluoromethyl)-3-biphenylyl)methyl)-1-phenylethanamine: 3
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Biphenyl Compounds: 7
        N-((6-(methyloxy)-4'-(trifluoromethyl)-3-biphenylyl)methyl)-1-phenylethanamine: 3

Experts

1.	Henley, Charles: 2 articles (03/2011 - 08/2009)
2.	Aguilera-Tejero, Escolastico: 1 article (03/2011)
3.	Almaden, Yolanda: 1 article (03/2011)
4.	Estepa, Jose Carlos: 1 article (03/2011)
5.	Lopez, Ignacio: 1 article (03/2011)
6.	Martinez-Moreno, Julio: 1 article (03/2011)
7.	Mendoza, Francisco J: 1 article (03/2011)
8.	Rodriguez, Mariano: 1 article (03/2011)
9.	Rodriguez-Ortiz, Maria E: 1 article (03/2011)
10.	Cattley, Russ: 1 article (08/2009)

Related Diseases

1.	Secondary Hyperparathyroidism 08/15/2009 - "In addition, AMG 641 prevented the defects in trabecular bone volume, trabecular number, and bone mineralization, as well as increases in trabecular spacing in this rodent model of secondary hyperparathyroidism. " 02/01/2008 - "When used in combination with paricalcitol, AMG 641 provided excellent control of secondary hyperparathyroidism and prevented mortality associated with the use of vitamin D derivatives without causing tissue calcification." 02/01/2008 - "We investigated the effect of calcitriol, paricalcitol, and the calcimimetic AMG 641 on soft-tissue calcification in uremic rats with secondary hyperparathyroidism. " 08/15/2009 - "The aim of this study was to determine the effects of the research calcimimetic AMG 641 (Amgen, Inc., Thousand Oaks, CA) or calcitriol (Sigma Aldrich Corporation, St. Louis, MO) on vascular calcification in a rodent model of progressive uremia with accompanying secondary hyperparathyroidism induced by dietary adenine. "
2.	Vascular Calcification 08/15/2009 - "The calcimimetic AMG 641 abrogates parathyroid hyperplasia, bone and vascular calcification abnormalities in uremic rats." 08/15/2009 - "AMG 641 significantly reduced calcium-phosphorus product (CaxP) and significantly attenuated the development of both parathyroid hyperplasia and vascular calcification. " 08/15/2009 - "The aim of this study was to determine the effects of the research calcimimetic AMG 641 (Amgen, Inc., Thousand Oaks, CA) or calcitriol (Sigma Aldrich Corporation, St. Louis, MO) on vascular calcification in a rodent model of progressive uremia with accompanying secondary hyperparathyroidism induced by dietary adenine. "
3.	Uremia 08/15/2009 - "The uremia-induced increases in serum PTH levels were significantly attenuated by both AMG 641 (>90%) and calcitriol (approximately 50%). " 08/15/2009 - "The aim of this study was to determine the effects of the research calcimimetic AMG 641 (Amgen, Inc., Thousand Oaks, CA) or calcitriol (Sigma Aldrich Corporation, St. Louis, MO) on vascular calcification in a rodent model of progressive uremia with accompanying secondary hyperparathyroidism induced by dietary adenine. "
4.	Hyperplasia 08/15/2009 - "The calcimimetic AMG 641 abrogates parathyroid hyperplasia, bone and vascular calcification abnormalities in uremic rats." 08/15/2009 - "AMG 641 significantly reduced calcium-phosphorus product (CaxP) and significantly attenuated the development of both parathyroid hyperplasia and vascular calcification. "
5.	Hypercalcemia (Milk Alkali Syndrome) 03/01/2011 - "Both AMG 641 and hypercalcemia induced MGP expression in the arterial wall in healthy and uremic rats. "

Related Drugs and Biologics

1.	Calcitriol (Calcijex)
2.	Adenine
3.	Vitamin D
4.	Phosphorus (Red Phosphorus)
5.	Calcium
6.	paricalcitol (Zemplar)