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PI 620

structure in first source

Also Known As:

PI-620; PI620 cpd

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - PI 620: 1
  - Thiophenes: 257
    - PI 620: 1
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiophenes: 257
    - PI 620: 1

Experts

1.	Alix, Sonia: 1 article (07/2009)
2.	Box, Gary: 1 article (07/2009)
3.	Chuckowree, Irina: 1 article (07/2009)
4.	Clarke, Paul A: 1 article (07/2009)
5.	De Haven Brandon, Alexis: 1 article (07/2009)
6.	Di Stefano, Francesca: 1 article (07/2009)
7.	Eccles, Suzanne A: 1 article (07/2009)
8.	Folkes, Adrian: 1 article (07/2009)
9.	Gowan, Sharon: 1 article (07/2009)
10.	Hayes, Angela: 1 article (07/2009)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2009 - "dosing in U87MG glioblastoma tumor xenografts in athymic mice, with treated/control values of 34% (66% inhibition) and 27% (73% inhibition) for PI-540 (50 mg/kg b.i.d.) and PI-620 (25 mg/kg b.i.d.), respectively. " 07/01/2009 - "GDC-0941 showed comparable in vitro antitumor activity to PI-103, PI-540, and PI-620 and exhibited 78% oral bioavailability in mice, with tumor exposure above 50% antiproliferative concentrations for >8 hours following 150 mg/kg p.o. "
2.	Glioblastoma (Glioblastoma Multiforme) 07/01/2009 - "dosing in U87MG glioblastoma tumor xenografts in athymic mice, with treated/control values of 34% (66% inhibition) and 27% (73% inhibition) for PI-540 (50 mg/kg b.i.d.) and PI-620 (25 mg/kg b.i.d.), respectively. "

Related Drugs and Biologics

1.	PI 540
2.	2- (1H- indazol- 4- yl)- 6- (4- methanesulfonylpiperazin- 1- ylmethyl)- 4- morpholin- 4- ylthieno(3,2- d)pyrimidine
3.	PI103