CYT997

01/01/2018 - "This study aims to investigate the efficacy of CYT997, a novel microtubule-disrupting agent, in head and neck squamous cell carcinomas (HNSCCs) and complete the autophagy-apoptosis puzzle involved in drug action. "
01/01/2018 - "Moreover, HCQ exhibits a good synergism with CYT997 on induction of apoptosis in HNSCC xenografts without cytotoxicity, suggesting combined treatment of CYT997 with autophagy inhibitors would increase the anticancer efficacy of CYT997. "
01/01/2018 - "• Combination of autophagy inhibitors with CYT997 is more effective against HNSCC."
01/01/2019 - "Collectively, our data unveil the mechanism involved in mediating CYT997 action, and provide preclinical rationale for possible clinical application of CYT997 as a novel therapeutic strategy against aggressive HNSCC."
01/01/2018 - "We report here that CYT997 exhibits anticancer activity by triggering oxidative stress-associated apoptosis in HNSCC cells. "

06/23/2020 - "CYT997, a novel microtubule-targeting agent, recently has been identified to be a promising anticancer candidate for the treatment of cancers; however, the effects of CYT997 in GC remain largely unknown. "
01/31/2019 - "Finally, CYT997 prominently reduced tumor growth in vivo. "
01/31/2019 - "BALB/c-nu mice were inoculated with 143B tumor cells to investigate the in vivo effect of CYT997. "
01/31/2019 - "CYT997 (lexibulin) is a novel potent microtubule-targeting agent with various anticancer activities, such as proliferation inhibition, vascular disruption, and cell cycle arrest and apoptosis induction, in multiple cancers. "
08/01/2013 - "The orally active microtubule-depolymerizing agent CYT997 is potently cytotoxic to a variety of tumors in vitro and in vivo. "

01/01/2019 - "Moreover, the capacity of invasive HNSCC cells to form pulmonary metastases was significantly blocked with CYT997 treatment, indicating that the diminishment of EMT traits contributes to CYT997-suppressed metastasis. "
01/01/2019 - "Here, we report that CYT997, a novel microtubule-disrupting agent, exerts strong activity in inhibiting HNSCC cell invasion and metastasis. "
01/01/2019 - "These findings support a critical role of ATP levels in cell invasion and metastasis under the influence of CYT997. "
12/01/2011 - "Furthermore, repeat dosing of CYT997 at 10 mg/kg and above (intraperitoneally, b.i.d.) was shown to effectively inhibit development of liver metastases. "
12/01/2017 - "Moreover, the combination of dasatinib and CYT997 exhibited a superior inhibitory effect on tumor growth and metastasis compared with either of the drugs alone. "

08/01/2013 - "The microtubule depolymerizing agent CYT997 effectively kills acute myeloid leukemia cells via activation of caspases and inhibition of PI3K/Akt/mTOR pathway proteins."

06/23/2020 - "CYT997 induces autophagy and apoptosis in gastric cancer by triggering mitochondrial ROS accumulation to silence JAK2/STAT3 pathway. "
06/23/2020 - "CYT997 inhibited gastric cancer cell proliferation and induced cell apoptosis and triggered autophagy. "
06/23/2020 - "Gastric cancer patient-derived xenograft (PDX) model was used to evaluate its antitumor activity of CYT997 in vivo. "
06/23/2020 - "In addition, CYT997 inhibited growth of gastric cancer patient-derived xenograft (PDX) tumors. "