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neolamellarin A

from the sponge Dendrilla nigra; structure in first source

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrroles: 369
      - neolamellarin A: 2

Experts

1.	Dong, Huijuan: 1 article (01/2019)
2.	Li, Guangzhe: 1 article (01/2019)
3.	Li, Yueqing: 1 article (01/2019)
4.	Ma, Yao: 1 article (01/2019)
5.	Shao, Kun: 1 article (01/2019)
6.	Shao, Yujie: 1 article (01/2019)
7.	Wang, Shisheng: 1 article (01/2019)
8.	Wu, Xiaodan: 1 article (01/2019)
9.	Zhao, Weijie: 1 article (01/2019)
10.	Arafeh, Khaled M: 1 article (07/2009)

Related Diseases

1.

Hypoxia (Hypoxemia)

01/01/2019 - "Structure-activity relationships study of neolamellarin A and its analogues as hypoxia inducible factor-1 (HIF-1) inhibitors."
07/01/2009 - "Synthesis of neolamellarin A, an inhibitor of hypoxia-inducible factor-1."
07/01/2009 - "Neolamellarin A, a metabolite isolated from the sponge Dendrilla nigra, was found to inhibit hypoxia-inducible factor-1 (HIF-1) activation by 26% at 10 microM concentration and inhibition of HIF-1 has become a major antitumor molecular target. "
01/01/2019 - "The novel marine pyrrole alkaloid neolamellarin A derived from sponge has been shown to inhibit hypoxia-induced HIF-1 activity. "

Related Drugs and Biologics

1.	Pyrroles
2.	Dihydrotachysterol (AT 10)
3.	Alkaloids