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denosomin

structure in first source

Networked: 4 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Tohda, Chihiro: 4 articles (01/2016 - 09/2009)
2.	Matsuya, Yuji: 3 articles (12/2015 - 09/2009)
3.	Shigyo, Michiko: 2 articles (01/2016 - 02/2013)
4.	Sugimoto, Kenji: 2 articles (12/2015 - 02/2013)
5.	Teshigawara, Kiyoshi: 2 articles (02/2013 - 09/2009)
6.	Hayashi, Yusuke: 1 article (12/2015)
7.	Minato, Daishiro: 1 article (12/2015)
8.	Terasaki, Sayuri: 1 article (12/2015)
9.	Yajima, Hisanari: 1 article (12/2015)
10.	Kuboyama, Tomoharu: 1 article (02/2013)

Related Diseases

1.	Spinal Cord Injuries (Spinal Cord Injury) 01/01/2016 - "We previously reported that denosomin improved motor dysfunction in mice with a contusive spinal cord injury (SCI). " 02/01/2013 - "A novel compound, denosomin, ameliorates spinal cord injury via axonal growth associated with astrocyte-secreted vimentin."
2.	Cicatrix (Scar) 02/01/2013 - "Denosomin improved hind limb motor dysfunction and axonal growth, especially in the 5-HT-positive tracts across the scar and increased the density of astrocytes. "
3.	Alzheimer Disease (Alzheimer's Disease) 12/04/2015 - "Synthesis of Denosomin-Vitamin D3 Hybrids and Evaluation of Their Anti-Alzheimer's Disease Activities." 09/03/2009 - "Synthesis of sominone and its derivatives based on an RCM strategy: discovery of a novel anti-Alzheimer's disease medicine candidate "denosomin"." 12/04/2015 - "As an extension of previously conducted studies on developing an anti-Alzheimer's disease agent, denosomin (1-deoxy-24-norsominone, an artificial inducer of neurite elongation), derivatives were designed and synthesized based on the hypothesis that our denosomin would exhibit axonal extension activity via a 1,25D(3)-membrane-associated, rapid response steroid-binding protein (1,25D(3)-MARRS) pathway. "
4.	Gliosis 02/01/2013 - "Denosomin increased the ratio of astrocytes that secrete vimentin as an axonal growth facilitator, which, we propose enhances axonal growth beyond the glial scar and promotes functional recovery in SCI mice. " 02/01/2013 - "Denosomin increased the number of vimentin-expressing astrocytes inside glial scars of SCI mice, and 5-HT-positive axonal growth occurred in a vimentin-associated manner. "

Related Drugs and Biologics

1.	Vimentin
2.	Steroids
3.	Carrier Proteins (Binding Protein)
4.	Cholecalciferol (Vitamin D3)
5.	sominone