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1- ethyl- 5- (5- ((4- methyl- 1- piperazinyl)methyl)- 1,3,4- oxadiazol- 2- yl)- N- (tetrahydro- 2H- pyran- 4- yl)- 1H- pyrazolo(3,4- b)pyridin- 4- amine

structure in first source

Also Known As:

EPPA-1

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - 1-ethyl-5-(5-((4-methyl-1-piperazinyl)methyl)-1,3,4-oxadiazol-2-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo(3,4-b)pyridin-4-amine: 1
  - Piperazines: 26
    - 1-ethyl-5-(5-((4-methyl-1-piperazinyl)methyl)-1,3,4-oxadiazol-2-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo(3,4-b)pyridin-4-amine: 1

Experts

1.	Ball, Doug: 1 article (09/2009)
2.	Barnette, Mary S: 1 article (09/2009)
3.	Capper-Spudich, Elizabeth A: 1 article (09/2009)
4.	Davis, T Gregg: 1 article (09/2009)
5.	Ferrari, Livia: 1 article (09/2009)
6.	Knowles, Richard G: 1 article (09/2009)
7.	Kou, Jen-Pyng: 1 article (09/2009)
8.	Lucas, Fiona S: 1 article (09/2009)
9.	Nials, Anthony T: 1 article (09/2009)
10.	Peterson, John J: 1 article (09/2009)

Related Diseases

1.	Vomiting 09/01/2009 - "These data validate rat pica feeding as a surrogate for PDE4 inhibitor-induced emesis in higher species, and identify EPPA-1 as a novel PDE4 inhibitor with an improved therapeutic index." 09/01/2009 - "The low and high emetogenic activities of EPPA-1 and rolipram, respectively, detected in the pica model were confirmed in a second surrogate model of emesis, reversal of alpha(2)-adrenoceptor-mediated anesthesia in the mouse. " 09/01/2009 - "The rank order of therapeutic indices derived in the rat [(pica D(50))/(neutrophilia D(50))] was EPPA-1 (578) > roflumilast (6.4) > cilomilast (1.4) > rolipram (0.15), consistent with the rank order derived in the ferret [(emesis D(50))/(neutrophilia D(50))]. " 09/01/2009 - "Pica, the consumption of non-nutritive substances in response to gastrointestinal stress, was used as a surrogate measure for emesis, giving a rank-order potency of rolipram (D(50) = 0.495 mg/kg) > roflumilast (1.6) > cilomilast (6.4) > EPPA-1 (24.3). "
2.	Pica (Geophagia) 09/01/2009 - "These data validate rat pica feeding as a surrogate for PDE4 inhibitor-induced emesis in higher species, and identify EPPA-1 as a novel PDE4 inhibitor with an improved therapeutic index." 09/01/2009 - "The low and high emetogenic activities of EPPA-1 and rolipram, respectively, detected in the pica model were confirmed in a second surrogate model of emesis, reversal of alpha(2)-adrenoceptor-mediated anesthesia in the mouse. " 09/01/2009 - "The rank order of therapeutic indices derived in the rat [(pica D(50))/(neutrophilia D(50))] was EPPA-1 (578) > roflumilast (6.4) > cilomilast (1.4) > rolipram (0.15), consistent with the rank order derived in the ferret [(emesis D(50))/(neutrophilia D(50))]. " 09/01/2009 - "Pica, the consumption of non-nutritive substances in response to gastrointestinal stress, was used as a surrogate measure for emesis, giving a rank-order potency of rolipram (D(50) = 0.495 mg/kg) > roflumilast (1.6) > cilomilast (6.4) > EPPA-1 (24.3). "

Related Drugs and Biologics

1.	Phosphodiesterase 4 Inhibitors
2.	Rolipram
3.	Cilomilast
4.	Roflumilast

Related Therapies and Procedures

1.	Anesthesia