TPC-Ahx-ATWLPPR

conjugation of photosensitizing agent (5-(4-carboxyphenyl)-10,15,20-triphenyl-chlorin (TPC) via a spacer 6-aminohexanoic acid (Ahx) to a heptapeptide (ATWLPPR); specific for the VEGF receptor neuropilin-1 (NRP-1)

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Barberi-Heyob, Muriel: 2 articles (05/2007 - 03/2006)
2.	Frochot, Céline: 2 articles (05/2007 - 03/2006)
3.	Guillemin, François: 2 articles (05/2007 - 03/2006)
4.	Thomas, Noémie: 2 articles (05/2007 - 03/2006)
5.	Tirand, Loraine: 2 articles (05/2007 - 03/2006)
6.	Dodeller, Marc: 1 article (05/2007)
7.	Dumas, Dominique: 1 article (05/2007)
8.	Maunit, Benoît: 1 article (05/2007)
9.	Pinel, Sophie: 1 article (03/2006)
10.	Trinquet, Eric: 1 article (03/2006)

Related Diseases

1.	Neoplasms (Cancer) 03/10/2006 - "Pharmacokinetic analysis in nude mice xenografted with U87 human malignant glioma cells revealed relevant tumor levels as soon as 1 h after intravenous injection of TPC-Ahx-ATWLPPR, and a rapid elimination from the blood compartment. " 05/01/2007 - "Because angiogenic endothelial cells of the tumor vasculature represent an interesting target to potentiate the antivascular effect of photodynamic therapy, we recently described the conjugation of a photosensitizer [5-(4-carboxyphenyl)-10,15,20-triphenylchlorin (TPC)], via a spacer [6-aminohexanoic acid (Ahx)], to a vascular endothelial growth factor receptor-specific heptapeptide [H-Ala-Thr-Trp-Leu-Pro-Pro-Arg-OH (ATWLPPR)] and showed that TPC-Ahx-ATWLPPR binds to neuropilin-1. "
2.	Glioma (Gliomas) 05/01/2007 - "TPC-Ahx-ATWLPPR was stable in vitro in human and mouse plasma for at least 24 h at 37 degrees C but, following i.v. injection in glioma-bearing nude mice, was degraded in vivo to various rates, depending on the organ considered. " 03/10/2006 - "Pharmacokinetic analysis in nude mice xenografted with U87 human malignant glioma cells revealed relevant tumor levels as soon as 1 h after intravenous injection of TPC-Ahx-ATWLPPR, and a rapid elimination from the blood compartment. "

Related Drugs and Biologics

1.	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)
2.	Neuropilin-1
3.	Photosensitizing Agents (Photosensitizers)
4.	Aminocaproic Acid (6 Aminocaproic Acid)
5.	hydroxide ion
6.	Ala-Thr-Trp-Leu-Pro-Pro-Arg

Related Therapies and Procedures

1.	Photochemotherapy (Photodynamic Therapy)
2.	Intravenous Injections