malanin

cytotoxic glycoprotein with the molecular weight of 61 kDa from the seeds of Malania oleifera

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

1.	Neoplasms (Cancer) 08/01/2009 - "Malanin exhibited highly cytotoxic activities against cancer cell lines (HeLa, PC-12, MCF-7, K562) and non-cancer cell lines (Vero and MDCK), producing IC(50) values of 0.15+/-0.08, 7.71+/-0.24, 11.20+/-0.02, 15.80+/-0.09, 2.79+/-0.05 and 3.92+/-0.01 nM, respectively. " 12/01/2014 - "A novel protein with anti-tumor activities named malanin was isolated and purified from an endemic plant in Yunnan and Guangxi provinces. "
2.	Melanosis (Freckles) 12/01/1975 - "Melanosis coli is caused by deposits of malanin- or lipofuscin-containing pigments in the colon mucosa; it is a conspicuous sign of long standing abuse of anthrachinonic laxatives. "
3.	Melanoma (Melanoma, Malignant) 01/01/1984 - "Thiouracil shows particular promise because of its incorporation during malanin synthesis in growing melanoma. "
4.	Carcinoma (Carcinomatosis) 03/01/2009 - "A new toxic protein named malanin was isolated from seeds of Malania olei fera by hydrophobic chromatography, whose cytotoxic activities against carcinoma cells were very strong. "