NO2-Arg-Trim

a nitro-arginine derivative of trimebutine that attenuates pain induced by colorectal distension in conscious rats; structure in first source

Also Known As:

3,4,5-trimethoxybenzoic acid 2-(dimethylamino)-2-phenylbutyl ester-N5-(nitroamidino)-l-2,5-diaminopentanoate

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

1.	Pain (Aches) 05/01/2009 - "Moreover, the expression of several genes involved in inflammation and pain, as IL-1beta, TNFalpha, COX2 and iNOS, was up-regulated in colonic tissue from post-colitis rats and NO2-Arg-Trim, but not trimebutine, effectively reversed this effect. "
2.	Inflammation (Inflammations) 05/01/2009 - "Moreover, the expression of several genes involved in inflammation and pain, as IL-1beta, TNFalpha, COX2 and iNOS, was up-regulated in colonic tissue from post-colitis rats and NO2-Arg-Trim, but not trimebutine, effectively reversed this effect. "
3.	Hyperalgesia 05/01/2009 - " antinociceptive effect of NO2-Arg-Trim was maintained in a rodent model of post-inflammatory allodynia. "
4.	Colitis 05/01/2009 - "In summary, these data suggest that NO2-Arg-Trim inhibits nociception induced by CRD in both healthy and post-colitis, allodynic rats. " 05/01/2009 - "Moreover, the expression of several genes involved in inflammation and pain, as IL-1beta, TNFalpha, COX2 and iNOS, was up-regulated in colonic tissue from post-colitis rats and NO2-Arg-Trim, but not trimebutine, effectively reversed this effect. "

1.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
2.	Trimebutine