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benzyloxycarbonyl- methionyl- 2(S)- cyanopyrrolidine

prolylendopeptidase inhibitor
Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Krupina, N A: 4 articles (10/2013 - 01/2009)
2. Khlebnikova, N N: 4 articles (10/2013 - 01/2009)
3. Zolotov, N N: 4 articles (10/2013 - 01/2009)
4. Bogdanova, N G: 3 articles (10/2013 - 01/2009)
5. Kryzhanovskii, G N: 2 articles (02/2012 - 01/2009)
6. Orlova, I N: 1 article (06/2013)
7. Kushnareva, E Yu: 1 article (02/2012)

Related Diseases

1. Depressive Disorder (Melancholia)
01/01/2009 - "Effects of prolylendopeptidase inhibitor benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine on experimental depressive syndrome development in rats."
06/01/2013 - "Effect of prolyl endopeptidase inhibitor benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine on the course of experimental depressive syndrome in rats."
01/01/2009 - "Model of experimental depressive syndrome in rats induced by repeated systemic injection of proneurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine showed that chronic injection of prolylendopeptidase inhibitor benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine 30 min before pro-neurotoxin injection prevents the development of a number of depressive syndrome symptoms such as behavioral despair and biorhythmic disorders in forced swimming test, precludes the increase in anxiety-phobic level, prevents reduction of relative thymus mass. "
06/01/2013 - "The effects of noncompetitive prolyl endopeptidase inhibitor benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine were studied in rats with the experimental dopamine deficiency-dependent depressive syndrome induced by systemic injections of a pre-neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin for 14 days. "
10/01/2013 - "A noncompetitive synthetic inhibitor of prolyl endopeptidase benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine (1.0 mg/kg intraperitoneally for 2 weeks) prevented the increase in activity of prolyl endopeptidase in the frontal cortex, striatum, and hypothalamus and activation of dipeptidyl peptidase IV in the frontal cortex of rats with experimental dopamine deficiency-dependent depressive syndrome caused by administration of proneurotoxin MPTP (2 weeks). "

Related Drugs and Biologics

1. prolyl oligopeptidase (prolyl endopeptidase)
2. 1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)
3. Proline (L-Proline)
4. Peptide Hydrolases (Proteases)
5. Dopamine (Intropin)
6. Dipeptidyl Peptidase 4 (Dipeptidyl Peptidase IV)
7. Imipramine (Janimine)

Related Therapies and Procedures

1. Injections