HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

BX-2819

a potent inhibitor of heat-shock protein-90; structure in first source

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Triazoles: 1533
      - BX-2819: 1

Experts

1.	Adler, Marc: 1 article (07/2009)
2.	Arnaiz, Damian O: 1 article (07/2009)
3.	Biroc, Sandra L: 1 article (07/2009)
4.	Bryant, Judi: 1 article (07/2009)
5.	Buckman, Brad: 1 article (07/2009)
6.	Chang, Zheng: 1 article (07/2009)
7.	Chen, Deborah: 1 article (07/2009)
8.	Dinter, Harald: 1 article (07/2009)
9.	Emayan, Kumar: 1 article (07/2009)
10.	Feldman, Richard I: 1 article (07/2009)

Related Diseases

1.

Neoplasms (Cancer)

07/01/2009 - "These data support further studies to assess the potential of BX-2819 and related analogs for the treatment of cancer."
07/01/2009 - "In a panel of four cancer cell lines, BX-2819 blocked growth with an average IC(50) value of 32 nM (range of 7-72 nM). "
07/01/2009 - "Efficacy studies demonstrated that treatment with BX-2819 significantly inhibited the growth of NCI-N87 and HT-29 tumors in nude mice, consistent with pharmacodynamic studies showing inhibition of heat-shock protein-90 client protein expression in tumors for greater than 16 h after dosing. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)