((E)- 3- amino- 5- (4- heptylphenyl)- 3- (hydroxymethyl)pent- 1- enyl)phosphonic acid

structure in first source

Also Known As:

((E,3R)-3-amino-5-(4-heptylphenyl)-3-(hydroxymethyl)pent-1-enyl)phosphonic acid; ((E,3S)-3-amino-5-(4-heptylphenyl)-3-(hydroxymethyl)pent-1-enyl)phosphonic acid; (R)-FTY720 vinylphosphonate; (S)-FTY720 vinylphosphonate; FTY720 vinylphosphonate

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Organophosphorus Compounds: 300
  - Organophosphonates: 424
    - ((E)-3-amino-5-(4-heptylphenyl)-3-(hydroxymethyl)pent-1-enyl)phosphonic acid: 2

Experts

1.	Bittman, Robert: 2 articles (06/2013 - 10/2010)
2.	Pyne, Nigel J: 2 articles (06/2013 - 10/2010)
3.	Pyne, Susan: 2 articles (06/2013 - 10/2010)
4.	Tonelli, Francesca: 2 articles (06/2013 - 10/2010)
5.	Alossaimi, Manal: 1 article (06/2013)
6.	Berdyshev, Evgeny: 1 article (06/2013)
7.	Gorshkova, Irina: 1 article (06/2013)
8.	Natarajan, Viswanathan: 1 article (06/2013)
9.	Watson, David G: 1 article (06/2013)
10.	Lim, Keng Gat: 1 article (10/2010)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 10/01/2010 - "We demonstrate here that FTY720 (Fingolimod) and (S)-FTY720 vinylphosphonate are novel inhibitors of SK1 catalytic activity and induce the proteasomal degradation of this enzyme in human pulmonary artery smooth muscle cells, MCF-7 breast cancer cells and androgen-independent LNCaP-AI prostate cancer cells. " 10/01/2010 - "FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells." 06/10/2013 - "We have now investigated the effects of three SK inhibitors (SKi, (S)-FTY720 vinylphosphonate, and (R)-FTY720 methyl ether) on metabolite and sphingolipid levels in androgen-sensitive LNCaP and androgen-independent LNCaP-AI prostate cancer cells. "
2.	Breast Neoplasms (Breast Cancer) 10/01/2010 - "We demonstrate here that FTY720 (Fingolimod) and (S)-FTY720 vinylphosphonate are novel inhibitors of SK1 catalytic activity and induce the proteasomal degradation of this enzyme in human pulmonary artery smooth muscle cells, MCF-7 breast cancer cells and androgen-independent LNCaP-AI prostate cancer cells. " 10/01/2010 - "FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells."

Related Drugs and Biologics

1.	Androgens
2.	Fingolimod Hydrochloride (FTY720)
3.	Sphingolipids
4.	Ether (Diethyl Ether)
5.	Enzymes
6.	sphingosine kinase