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bis((2- oxindol- 3- ylimino)- 2- (2- aminoethyl)pyridine- N,N')copper(II)

induces mitochondrial damage; structure in first source

Also Known As:

(Cu(isaepy)2)

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Cardaci, Simone: 2 articles (08/2011 - 07/2009)
2.	Filomeni, Giuseppe: 2 articles (08/2011 - 07/2009)
3.	Rotilio, Giuseppe: 2 articles (08/2011 - 07/2009)
4.	Ciriolo, Maria Rosa: 1 article (08/2011)
5.	Da Costa Ferreira, Ana Maria: 1 article (08/2011)
6.	Ciriolo, Maria R: 1 article (07/2009)
7.	Da Costa Ferreira, Ana M: 1 article (07/2009)
8.	Graziani, Ilaria: 1 article (07/2009)
9.	Piccirillo, Sara: 1 article (07/2009)

Related Diseases

1.	Neuroblastoma 08/01/2011 - "Metabolic oxidative stress elicited by the copper(II) complex [Cu(isaepy)2] triggers apoptosis in SH-SY5Y cells through the induction of the AMP-activated protein kinase/p38MAPK/p53 signalling axis: evidence for a combined use with 3-bromopyruvate in neuroblastoma treatment."
2.	Neoplasms (Cancer) 08/01/2011 - "Overall, the results suggest that NADPH deriving from the pentose phosphate pathway contributes to PCN resistance to [Cu(isaepy)(2)] toxicity and propose its employment in combination with 3BrPA as possible tool for cancer treatment."
3.	Carcinoma (Carcinomatosis) 07/01/2009 - "Moreover, gastric and cervix carcinoma AGS and HeLa cells, which rely most of their ATP production on oxidative phosphorylation, show a marked sensitivity toward Cu(isaepy)(2). "

Related Drugs and Biologics

1.	AMP-Activated Protein Kinases
2.	Pregnenolone Carbonitrile (PCN)
3.	NADP (NADPH)
4.	Copper
5.	Adenosine Triphosphate (ATP)
6.	bromopyruvate