|1.||Clarke, Nick: 1 article (10/2015)|
|2.||Clarke, Graham W: 1 article (10/2015)|
|3.||Singh, Dave: 1 article (10/2015)|
|4.||Christensen, Jared: 1 article (10/2015)|
|5.||Siew, Leonard: 1 article (10/2015)|
|6.||Greenaway, Steve: 1 article (10/2015)|
|7.||Perros-Huguet, Christelle: 1 article (10/2015)|
|8.||Plumb, Jonathan: 1 article (10/2015)|
|9.||Kilty, Iain: 1 article (10/2015)|
|10.||Tan, Lisa: 1 article (10/2015)|
|1.||Chronic Obstructive Pulmonary Disease (COPD)
03/01/2015 - "Results from animal models provide a clear rationale for developing p38 inhibitors for COPD, and appear to be (partially) validated by the efficacy seen with PH-797804 and losmapimod. "
08/01/2013 - "PH-797804 demonstrated improvements over placebo in lung function parameters and dyspnoea in patients with moderate to severe COPD. "
08/01/2013 - "To evaluate the efficacy and safety of PH-797804, a potent and selective p38 inhibitor, in adults with moderate to severe COPD (Global Initiative for Chronic Obstructive Lung Disease stage II/III). "
08/01/2013 - "Efficacy and safety of the oral p38 inhibitor PH-797804 in chronic obstructive pulmonary disease: a randomised clinical trial."
10/01/2015 - "PH-797804 had the greatest impact on neutrophilic airway inflammation. "
12/01/2009 - "Furthermore, PH-797804 demonstrates robust anti-inflammatory activity in chronic disease models, significantly reducing both joint inflammation and associated bone loss in streptococcal cell wall-induced arthritis in rats and mouse collagen-induced arthritis. "
12/01/2009 - "PH-797804 is an ATP-competitive, readily reversible inhibitor of the alpha isoform of human p38 MAP kinase, exhibiting a K(i) = 5.8 nM. In human monocyte and synovial fibroblast cell systems, PH-797804 blocks inflammation-induced production of cytokines and proinflammatory mediators, such as prostaglandin E(2), at concentrations that parallel inhibition of cell-associated p38 MAP kinase. "
|4.||Chronic Disease (Chronic Diseases)
|1.||p38 Mitogen-Activated Protein Kinases
|3.||Adenosine Triphosphate (ATP)