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SB 408124

a hypocretin receptor type 1 (HcrtR1) antagonist

Also Known As:

SB-408124; SB408124

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - Phenylurea Compounds: 1
      - SB 408124: 3
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenylurea Compounds: 1
        SB 408124: 3

Experts

1.	Okui, Rikuya: 1 article (01/2019)
2.	Yamamoto, Kouichi: 1 article (01/2019)
3.	Yamatodani, Atsushi: 1 article (01/2019)
4.	Arseth, Heather A: 1 article (08/2018)
5.	Hurley, Seth W: 1 article (08/2018)
6.	Johnson, Alan Kim: 1 article (08/2018)
7.	Shimoyama, Megumi: 1 article (02/2017)
8.	Shimoyama, Naohito: 1 article (02/2017)
9.	Toyama, Satoshi: 1 article (02/2017)

Related Diseases

1.	Hyperalgesia 02/01/2017 - "The analgesic effect of orexin-A on oxaliplatin-induced mechanical allodynia was completely antagonized by prior intraperitoneal injection of SB-408124 (orexin type-1 receptor antagonist), but not by prior intraperitoneal injection of TCS-OX2-29 (orexin type-2 receptor antagonist). "
2.	Dehydration (Water Stress) 08/01/2018 - "Bilateral microinjection of the Ox Type I receptor antagonist SB-408124 into the VTA prior to acute extracellular dehydration attenuated fluid intake. "
3.	Anorexia 01/01/2019 - "The effect of the H4 receptor antagonist on cisplatin-induced anorexia in mice was antagonized by an orexin OX2 receptor antagonist (JNJ10397049, 5 mg/kg) rather than an orexin OX1 receptor antagonist (SB408124, 30 mg/kg). "

Related Drugs and Biologics

1.	Orexins
2.	Orexin Receptors
3.	Cisplatin (Platino)
4.	Analgesics (Analgesic Drugs)
5.	Oxaliplatin (Eloxatin)
6.	JNJ 10397049

Related Therapies and Procedures

1.	Intraperitoneal Injections