IGOB131

Anti-Obesity Agents; seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controlled investigation; 1/2009

Networked: 4 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ngondi, Judith L: 2 articles (03/2009 - 11/2008)
2.	Oben, Julius E: 2 articles (03/2009 - 11/2008)
3.	Gavara, Swapna: 1 article (05/2012)
4.	Kothari, Shil C: 1 article (05/2012)
5.	Shivarudraiah, Prasad: 1 article (05/2012)
6.	Soni, Madhu G: 1 article (05/2012)
7.	Venkataramaiah, Suresh Babu: 1 article (05/2012)
8.	Ross, Stephanie Maxine: 1 article (07/2011)
9.	Etoundi, Blanche C: 1 article (03/2009)
10.	Mbofung, Carl Mf: 1 article (03/2009)

Related Diseases

1.	Body Weight (Weight, Body) 05/01/2012 - "In the subchronic study, Sprague Dawley rats (20/sex/group) were gavaged with I. gabonensis extract (IGOB131) at dose levels of 0, 100, 1000 and 2500 mg/kg body weight (bw)/day for 90-days. " 07/01/2011 - "African mango (IGOB131): a proprietary seed extract of Irvingia gabonensis is found to be effective in reducing body weight and improving metabolic parameters in overweight humans." 03/02/2009 - "This study was therefore aimed at evaluating the effects of IGOB131, an extract of Irvingia gabonensis, on body weight and associated metabolic parameters in overweight human volunteers. " 03/02/2009 - "IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controlled investigation." 03/02/2009 - "Significant improvements in body weight, body fat, and waist circumference as well as plasma total cholesterol, LDL cholesterol, blood glucose, C-reactive protein, adiponectin and leptin levels were observed in the IGOB131 group compared with the placebo group. "
2.	Overweight 07/01/2011 - "African mango (IGOB131): a proprietary seed extract of Irvingia gabonensis is found to be effective in reducing body weight and improving metabolic parameters in overweight humans." 03/02/2009 - "This study was therefore aimed at evaluating the effects of IGOB131, an extract of Irvingia gabonensis, on body weight and associated metabolic parameters in overweight human volunteers. " 03/02/2009 - "IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controlled investigation."
3.	Obesity 11/13/2008 - "IGOB131 may play an important multifaceted role in the control of adipogenesis and have further implications in in-vivo anti obesity effects by targeting the PPAR gamma gene, a known contributory factor to obesity in humans." 11/13/2008 - "We investigated whether an Irvingia gabonensis seed extract (IGOB131) would provide a more beneficial comprehensive approach influencing multiple mechanisms and specifically PPAR gamma, leptin and adiponectin gene expressions, important in anti-obesity strategies. "
4.	Chromosome Aberrations (Chromosome Abnormalities) 05/01/2012 - "The mutagenicity as evaluated by Ames assay, in vitro and in vivo chromosomal aberration test and in vivo micronucleus assay did not reveal any genotoxicity of IGOB131. "

Related Drugs and Biologics

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5.	LDL Cholesterol
6.	Cholesterol
7.	C-Reactive Protein
8.	Blood Glucose (Blood Sugar)